Perfil Lipoproteico

7/23/2019 Perfil Lipoproteico

http://slidepdf.com/reader/full/perfil-lipoproteico 1/41

UNIVERSIDADE FEDERAL DE PERNAMBCO

CENTRO DE CIÊNCIAS BIOLÓGICAS

CURSO DE BIOMEDICINA

AÍLA LIMA DE MELO

PERFIL LIPOPROTÉICO DA POPULAÇÃO RESIDENTE NA

MATA NORTE DO ESTADO DE PERNAMBUCO

RECIFE

2013



AÍLA LIMA DE MELO



Trabalh !" C#$l%&' !" $%r&a(r"&"#)a! a C%r& !" Gra!%a*' "+B,+"!,$,#a !a U#,-"r&,!a!" F"!"ral !"P"r#a+b%$ .UFPE/ C"#)r !" C,#$,a&B,l,$a& $+ r"%,&,) (ar$,al (arab)"#*' ! ra% !" Ba$har"l "+B,+"!,$,#a4

Orientação5 M&$4 Mar"6 7"#r8%"F"rr",ra E6"r)

Coorientação5 Carl& 7"#r,%" F%l#$,

P"r",ra Val"

RECIFE

2013



AÍLA LIMA DE MELO



M#ra9,a a(r-a!a "+ :::: ; :::: ; ::::

BANCA E<AMINADORA

:::::::::::::::::::::::::::::::::::::::::::

M&$4 Mar"6 7"#r8%" F"rr",ra E6"r) .Or,"#)a!r/Labra)r, !" I+%#(a)l,a !" =",> A&a+, .LI=A/

:::::::::::::::::::::::::::::::::::::::::::

M&$4 ?' L%,> @%,r,# !a S,l-a F,lh .M"+br/Labra)r, !" I+%#(a)l,a !" =",> A&a+, .LI=A/

:::::::::::::::::::::::::::::::::::::::::::

M&$4 Na)al,a C8b"ll" L,+a Ol,-",ra .M"+br/Labra)r, !" I+%#(a)l,a !" =",> A&a+, .LI=A/

:::::::::::::::::::::::::::::::::::::::::::

M&$4 Rb"r)a L%$,a#a ! Na&$,+"#) G!#" .M"+br/Labra)r, !" I+%#(a)l,a !" =",> A&a+, .LI=A/



D"%& +,#ha 9r*a " r"9,4 A& +"%& (a,&A!a+& " D"#,&" " ,r+'& Al,#" " L%$,a#a ("la+r " !"!,$a*'4



AGRADECIMENTOS

Ara!"* (r,+",ra+"#)" a D"%& (r %,ar +"%& (a&&& a) a%, +" &%&)"#)ar " $#$"!"r

9r*a& (ara $a+,#ha!a4 Pr ,l%+,#ar +"%& ("#&a+"#)& " +" a%!ar a !"rr%bar $a!a b&)$%l! $a+,#h

Ara!"* a& +"%& (a,& A!a+& " D"#,&" +"%& +a,r"& ""+(l&4 Obr,a!a (r $a!a,#$"#),- " r,"#)a*' ("la& ra*H"& "+ +"% 9a-r ("la (r"$%(a*' (ara %" "&),-"&&"&"+(r" a#!a#! ("l $a+,#h $rr")4 A& +,#ha& ,r+'& Al,#" " L%$,a#a (r )!a& a&!,&$%&&H"& $#&)r%),-a& (r )! a+r " $ar,#h %a#! (r"$,&",4 A& +"%& ),& ),a& a-&a-& (r,+& " (r,+a& %" &"+(r" "&),-"ra+ (r"&"#)"& a,#!a %" J !,&)K#$,a4 A +"%#a+ra! D, (r )! a+r $ar,#h (a$,#$,a " $+(r""#&' %" )"+ +" !"!,$a!

A +"% a+, " r,"#)a!r Mar"6 7"#r8%" F"rr",ra E6"r) %" $+ +%,)a (a$,#$,a "

a)"#*' !"!,$% ! &"% -al,& )"+( (ara +" %,ar "+ $a!a (a&& !"&)" )rabalh4 A& (r9"&&r"& Mar$& A#!r ?"l+a S%>a Da#8"ll8 Br%#"&6a " ?& L%,> ("la $#)r,b%,*'#a +,#ha -,!a a$a!+,$a " (r )a#)a ,#9l%#$,a #a +,#ha 9%)%ra -,!a (r9,&&,#al4 A A#!rGal-' ("la a%!a #& $l$%l& "&)a)&),$& !"&&" )rabalh

A& +"%& $l"a& !" $la&&" " a+,& (ara a -,!a ,#)",ra5 A#a =arl,#a Brbara M#)",rCa+,la Sa#)& C"l& Barb&a Clar,&&a A)a!" Clar,&&a R,b",r D," Mar),#& ?%a# L%,>7"rb"r) a+%r, Na)hal8a Ol,-",ra " Tal,)a Ara $%a& a+,>a!"& "+ al%+ ++"#) !"+,#ha -,!a +" 9,>"ra+ $r"&$"r $+ "&)%!a#)" " $+ ("&&a4 P"l& ++"#)& !" 9"l,$,!a!"

("r"#" %" $#-,-"+& " ("l& ++"#)& !" !,-"r&'

A )!& ! r%( Pr&("$+l " "%,(" !" 7"+a)l,a Labra)r,al ("l ,+"#& a(,$#$"!,! #"&)a r#a!a ("l $r"&$,+"#) $,"#)9,$ " ("&&al4 Ara!"* a )!& (r "&&")"+( %" (a&&a+& %#)& ("l& ,#+"r& ++"#)& !" al"r,a $+(a#h",r,&+ #!" a9"l,$,!a!" " %#,' &"+(r" "&),-"ra+ ,#)"ra!a&

A )!& %" +"&+ #' "&)a#! $,)a!& a%, )a#) $#)r,b%ra+ (ara a $#$l%&' !"&)a")a(a ara!"* ,+"#&a+"#)"4



N' &ab"#! %" "ra ,+(&&-"l 9, l " 9">

?"a# C$)"a%



MELO Ala L,+a P"r9,l l,((r),$ !a ((%la*' r"&,!"#)" #a Ma)a Nr)" ! "&)a! !"P"r#a+b%$4 20134 M#ra9,a .C%r& !" B,+"!,$,#a/ U#,-"r&,!a!" F"!"ral !"P"r#a+b%$ R"$,9" 20134

RESUMO

A& !,&l,(,!"+,a& &' "l"-a*H"& &r,$a& !" %+ % +a,& $+(#"#)"& &a#%#"&

!"$rr"#)"& !" !,&)rb,& "+ %al%"r 9a&" ! +")abl,&+ l,(!,$4 E&)" "$"&& (!" l"-ar

a a$+%l ,#)ra$"l%lar !" l,(!"& " !"(&,*' !& +"&+& "+ -a&& " )"$,!& "ra#!

a%+"#) ! r,&$ $ar!,-a&$%lar4 A (r"&"#)" +#ra9,a )"-" $+ b"),- !")"r+,#ar

("r9,l l,((r),$ "+ +ra!r"& !a Ma)a Nr)" ! "&)a! !" P"r#a+b%$4 E&)" "&)%! 9,

r"al,>a! $+ Q1 (a$,"#)"& $+ ,!a!" "#)r" 0 " a#&4 O& (r$"&&& a#al),$& 9ra+r"al,>a!& # Labra)r, !" A#l,&"& Cl#,$a& @UALI LAB .T,+baba PE/4 Fra+

$l")a!a& a+&)ra& !" &a#%" . +L/ "+ )%b& Vacutainer " &r 9, &"(ara! !a& h"+$,a&

(r $"#)r,9%a*' (ara a !&a"+ !" 7DL$4 A !")"r+,#a*' !" LDL$ 9, b),!a ("l

$l$%l !" Fr,"!"al!4 A +"!,a#a !" ,!a!" #a ((%la*' 9, !" Q a#&4 C#&,!"ra#! $+

!,&l,(,!+,$ (a$,"#)" $+ al)"ra*' "+ ("l +"#& %+a !a& 9ra*H"& ! ("r9,l l,((r)",$

a(r,+a!a+"#)" a +")a!" !& (ar),$,(a#)"& .0/ "#%a!r%&" $+ (r)a!r"& !"&&a

(a)l,a4 A 9ra*' 7DL$ b&"r-%&" al)"ra!a "+ 33 (a$,"#)"& !,9"r"#)"+"#)" !a LDL$%" "&)"-" al)"ra!a "+ a("#a& 1Q (a$,"#)"&4 A& $#$"#)ra*H"& !a& l,((r)"#a& (ra),$a+"#)"

#' !,9"r,ra+ "+ r"la*' a &" (ara (arK+")r 7DL$4 E+ r"la*' a LDL$ ,#!,-!%&

! &" 9"+,#,# a(r"&"#)ara+ -alr"& +a,& "l"-a!& .±DP W Q3/4 E#)r" & h+"#&

-alr +,+ "#$#)ra! !" LDL$ 9, !" 1XY +;!L "#%a#) %" #a& +%lh"r"& 9, !"

23Y +;!L4 A& !"#*a& $ar!,-a&$%lar"& r"(r"&"#)a+ %+ ra#!" (rbl"+a !" &a!" (bl,$a

# Bra&,l #"ra#! $%&)& # a)"#!,+"#) " #a& ba,a& h&(,)alar"&4 D"-"&" (r)a#)

,#)"#&,9,$ar "&9r*& #a !")"$*' (r"$$" (r"-"#*' " #a "!%$a*' "+ &a!" (ara +,#,+,>ar "&&"& ara-& %" )a#) $a%&a+ (r"%>& J %al,!a!" !" -,!a !a ((%la*'4

Paa!ra"#$%a!e& D,&l,(,!"+,a ("r9,l l,((r)",$ 7DL$ LDL$4



MELO Ala L,+a L,((r)",# (r9,l" ,# ((%la),# 9 Ma)a Nr)" r",# 9 P"r#a+b%$420134 M#ra(h .B,+"!,$,#" C%r&"/ F"!"ral U#,-"r&,)8 9 P"r#a+b%$ R"$,9" 2013

ABSTRACT

D8&l,(,!"+,a ,& ,#$r"a&"! &"r%+ 9 #" r +r" bl! $+(#"#)& r"&%l),# 9r+ a#8 (ha&"

!,&)%rba#$"& ,# l,(,! +")abl,&+4 Th,& "$"&& $a# l"a! ) a$$%+%la),# 9 ,#)ra$"ll%lar l,(,!&

a#! !"(&,),# ,# )h" &a+" -"&&"l& a#! ),&&%"& "#"ra),# ,#$r"a&"! $ar!,-a&$%lar r,&6 4 Th,&

+#ra(h a,+& ) !")"r+,#" )h" l,((r)",# (r9,l" ,# r"&,!"#)& ,# Ma)a Nr)" r",#

l$a)"! a) &)a)" 9 P"r#a+b%$4 Th,& &)%!8 a& $#!%$)"! ,)h Q1 (a),"#)& a"! b")""# 0

a#! 8"ar&4 Th" a#al8),$al (r$"!%r"& "r" ("r9r+"! ,# )h" Cl,#,$al Labra)r8

@UALILAB .T,+baba PE/4 Bl! &a+(l"& . +L/ "r" $ll"$)"! ,# Va$%)a,#"r )%b"& a#!

&"r%+ a& &"(ara)"! 9r+ bl! $"ll& b8 $"#)r,9%a),# 9r )h" +"a&%r"+"#) 9 7DL$4 Th"

!")"r+,#a),# 9 LDL $ a& b)a,#"! b8 )h" Fr,"!"al! "%a),#4 Th" +"!,a# a" 9 )h"

((%la),# a& Q 8"ar&4 C#&,!"r,# h !8&l,(,!"+,$ (a),"#)& ,)h al)"ra),#& ,# a) l"a&)

#" 9 )h" 9ra$),#& 9 )h" l,((r)",# (r9,l" a((r,+a)"l8 hal9 9 )h" (ar),$,(a#)& .40/

9ra+"! a& (a),"#)& ,)h )h,& (a)hl84 Th" 7DL$ a& $ha#"! ,# 33 (a),"#)& %#l,6" LDL$h,$h a& ab#r+al ,# 1Q (a),"#)&4 Th" $#$"#)ra),#& 9 l,((r)",#& har!l8 !,99"r r"ar!,#

&" 9r 7DL$ (ara+")"r4 I# r"la),# ) LDL$ 9"+al"& &h"! h,h"r -al%"& .ZSD W Q43/4

A+# +"# )h" +a,+%+ -al%" 9%#! ,# LDL$ a& 1X4Y + ; !L h"r"a& ,# +"# a&

234Y +;!L4 Car!,-a&$%lar !,&"a&"& ar" a +ar (%bl,$ h"al)h (rbl"+ ,# Bra>,l b%r!"#,#

$&)& ,# $ar" a#! ,# h&(,)al a!+,&&,#&4 Sh%l! )h"r"9r" ,#)"#&,98 "99r)& ,# )h" "arl8

!")"$),# (r"-"#),# a#! h"al)h "!%$a),# ) +,#,+,>" )h"&" !,&"a&"& )ha) $a%&" +%$h

!a+a" ) )h" %al,)8 9 l,9"4

'e(#)or*"& D8&l,(,!"+,a l,((r)",# (r9,l" 7DL$ LDL$4



LISTA DE FIGURAS

Fi+,ra -& E&%"+a "+ $r)" !" %+a l,((r)"#a44444444444444444444444444444444444444444444444444444444444444444441X

Fi+,ra .a& M")abl,&+ !a& L,((r)"#a&5 C,$l& ""# "#!"# " )ra#&(r)"

r"-"r&44444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444 1Q

Fi+,ra ./& M")abl,&+ h"(),$ !a& l,((r)"#a&44444444444444444444444444444444444444444444444444444444444444441Q

Fi+,ra 0& Pr$"&& !" 9r+a*' !a (la$a a)"r&$l"r),$a4444444444444444444444444444444444444444444444444444444422

viii



LISTA DE TABELAS E GR1FICOS

Ta/ea -& Valr"& !" r"9"r#$,a !& l,(!"& (ara ,#!,-!%& a$,+a !& 20 a#& !" ,!a!"444442

Ta/ea .& D,&)r,b%,*' !a a+&)ra !& r"&,!"#)"& !a Ma)a Nr)" ! "&)a! !"

P"r#a+b%$44444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444442X

Ta/ea 0& N-",& !" 7DL$ " LDL$ &"%#! &" #& r"&,!"#)"& !a Ma)a Nr)" ! "&)a!!" P"r#a+b%$444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444442

Gr23i$o -& P"r9,l l,((r)",$ #& r"&,!"#)"& !a Ma)a Nr)" ! "&)a! !" P"r#a+b%$

&"%#! & -alr"& r"$+"#!a!& ("la III D,r")r,>"& Bra&,l",ra& &br"

!,&l,(,!"+,a&44 444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444

4444444444444444444442

Gr23i$o .& R"la*' "#)r" $#$"#)ra*' !" 7DL$ " ,!a!" #& r"&,!"#)"& !a Ma)a Nr)" !

"&)a! !" P"r#a+b%$4444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444442Q

Gr23i$o 0& R"la*' "#)r" $#$"#)ra*' !" LDL$ " ,!a!" #& r"&,!"#)"& !a Ma)a Nr)" !

"&)a! !" P"r#a+b%$4444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444442Q

ix



LISTA DE ABRE4IATURAS E SIGLAS

IAM I#9ar) A%! ! M,$r!,

TG Tr,l,$"r!"

VLDL$ L,((r)"#a !" +%,)a ba,a !"#&,!a!"

LDL$ L,((r)"#a !" ba,a !"#&,!a!"

7DL$ L,((r)"#a !" al)a !"#&,!a!"

DCV D"#*a Car!,-a&$%lar

IMIP I#&),)%) !" M"!,$,#a I#)"ral Pr94 F"r#a#! F,%",ra

SUS S,&)"+a [#,$ !" Sa!"

N7ANES Na),#al 7"al)h a#! N%)r,),# Ea+,#a),# S%r-"8

x



SUM1RIO

LISTA DE FIGURAS444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444-,,,LISTA DE TABELAS E GR1FICOS444444444444444444444444444444444444444444444444444444444444444444444444444444444444,

LISTA DE ABRE4IATURAS E SIGLAS444444444444444444444444444444444444444444444444444444444444444444444444444444

-5 INTRODUÇÃO44444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444441.5 RE4ISÃO BIBLIOGR1FICA4444444444444444444444444444444444444444444444444444444444444444444444444444444444444441Y

2414 P"r9,l l,(!,$444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444441Y2424 @%,l+$r#&444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444441X2434 VLDL$l"&)"rl444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444441X244 LDL$l"&)"rl444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444441

244 7DL$l"&)"rl444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444441Q24Y4 Tr,l,$"r!"&44444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444442024X4 D,&l,(,!"+,a&4444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444421244 A)"r&$l"r&"4444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444421

05 OB6TI4OS44444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444233414 Ob"),- "ral4444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444233424 Ob"),-& "&("$9,$&4444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444423

75 METODOLOGIA4444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444442414 A+&)ra"+4444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444442424 Cr,)r,& !" ,#$l%&'4444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444442434 Cr,)r,& !" "$l%&'444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444442

44 Cl")a !" !a!&4444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444244 A#l,&" labra)r,al444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444424Y4 A#l,&" !" !a!&4444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444442Y

85 RESULTADOS44444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444442X95 DISCUSSÃO44444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444430:5 CONCLUS;ES444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444433<5 REFER=NCIAS4444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444443>5 ANE?OS4444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444443Q

Q414 Car)a !" a#%#$,a44444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444443QQ424 A(r-a*' C+,) !" \),$a44444444444444444444444444444444444444444444444444444444444444444444444444444444444444444440



MELO, A. L. Perfl lipoprotéico da população...

-5 INTRODUÇÃO

A& r!%ra& # $a& !& a#,+a,& " & l"& #& -"")a,& &' a& r"&"r-a& "#"r),$a&

+a,& ,+(r)a#)"& (ara ra#,&+ .MANSO 1QY/4 Para al+ !a 9%#*' !" r"&"r-a

"#"r),$a & l,(!"& )+ 9%#*H"& "&)r%)%ra,& %" %a#! a&&$,a!a& a %)ra& +l$%la&

rK#,$a& $%+(r"+ 9%#*H"& "&("$9,$a& .7ALPERN 1QQX/4 A& l,((r)"#a& (la&+),$a& &'

(ar)$%la& $+(l"a& +a$r+l"$%lar"& $#&),)%!a& (r +l$%la& (r),$a& " l,(!,$a& "

!,-,!"+&" "+ $la&&"&5 %,l+$r#& VLDL LDL 7DL .NAITO 2003 NELSON ") al4

2003/4 A 9%#*' (r,#$,(al !a& l,((r)"#a& (la&+),$a& (ar"$" &"r )ra#&(r)" !&

)r,l,$"r!"& " ! $l"&)"rl !& l$a,& !" r,"+ ] # ,#)"&),# .r,"+ ""#a/ " #

9a! .r,"+ "#!"#a/ ] (ara & l$a,& !" ar+a>"#a+"#) " %),l,>a*' .SC7IAVO ") al42003/4

A l# !& a#& )"+&" b&"r-a! %+a $r"&$"#)" (r"$%(a*' $+ ("r9,l l,(!,$

" &%a& ,+(l,$a*H"& #a& !"#*a& $ar!,-a&$%lar"&4 D"&,#a+&" !,&l,(,!"+,a& %

h,("rl,(,!"+,a& a& "l"-a*H"& &r,$a& !" %+ % +a,& $+(#"#)"& &a#%#"& !"$rr"#)"& !"

!,&)rb,& "+ %al%"r 9a&" ! +")abl,&+ l,(!,$ .C7ACRA ") al4 200/4 E&)" "$"&&

(!" l"-ar a a$+%l ,#)ra$"l%lar !" l,(!"& " !"(&,*' !& +"&+& "+ -a&& " )"$,!&

"ra#! a%+"#) ! r,&$ $ar!,-a&$%lar % a) +"&+ (a)l,a& )a,& $+5 a)"r&$l"r&",#9ar) a%! ! +,$r!, .IAM/ "&)"a)&" h"(),$a b"&,!a!" D,ab")"& M"ll,)%& T,( II

"#)r" %)ra& .FIL7O 2000/4

A a)"r&$l"r&" %+ (r$"&& +%l),9a)r,al (rr"&&,- " l"#) # %al h al)"ra*'

#a (ar"!" ar)"r,al .GOTTLIEB ") al4 200/4 A #"&" !a 9r+a*' !a (la$a !" a)"r+a

b,l,$a $+(l"a #!" h %+ $r"&$,+"#) (rr"&&,- !" l,((r)"#a #a $a+a!a ,#)ra "

")ra$"l%lar a&&$,a! a %+ (r$"&& $"l%lar (rl,9"ra),- $a&,#a#! !"(&,) !" )r+b

.LAURINDO 2000/4 S"%#! a& III D,r")r,>"& !a S$,"!a!" Bra&,l",ra !" Car!,l,a

.2001/ a !"#*a a)"r&$l"r),$a a (r,#$,(al $a%&a !" +r)" # Bra&,l4

D"&!" a !$a!a !" 0 ! &$%l (a&&a! !"&"#-l-"ra+&" ,#+"ra& b&"r-a*H"&

$l#,$a& "&)%!& ra#!+,>a!& $+ ra#!" a+&)ra"+ %" ("r+,),ra+ !")"r+,#ar $+

&"%ra#*a & 9a)r"& !" r,&$ +!,9,$-",& !"&)a& !"#*a& .BALTALI ") al4 2003/ "#)r" "l"&

"#$#)ra+&" )aba,&+ al$l,&+ &"!"#)ar,&+ " & hb,)& al,+"#)ar"&4

A("&ar !a al)a +r)al,!a!" (r !"#*a& $ar!,-a&$%lar"& # Bra&,l %a&" #' h !a!&

&br" #-"l !" l,((r)"#a& "+ ((%la*' $+ ,!a!" a-a#*a!a4




N"&&" &"#),! (r"&"#)" )rabalh b"),-a !")"r+,#ar ("r9,l l,((r),$ "

,!"#),9,$ar (&&-",& !,&l,(,!"+,a& %#) a& r"&,!"#)"& #a r",' !a Ma)a Nr)" ! "&)a! !"

P"r#a+b%$4




.5 RE4ISÃO BIBLIOGR1FICA

.5- PERFIL LIP@DICO

O& l,(!"& !"9,#"+ %+ $#%#) !" &%b&)K#$,a& %+,$a& %" a $#)rr, !a& %)ra&

$la&&"& !" $+(&)& rK#,$& #' &' $ara$)"r,>a!a& (r al%+ r%( 9%#$,#al $+%+ "

&,+ ("la &%a al)a &l%b,l,!a!" "+ &l-"#)"& rK#,$& " ,#&l%b,l,!a!" "+ %a4 O& l,(!"&

+a,& ,+(r)a#)"& ! (#) !" -,&)a 9,&,l,$ " $l#,$ &' & $,!& ra& &

)r,l,$"r!"& .TG/ & 9&9l,(!"& " $l"&)"rl4 O& $,!& ra& (!"+ &"r5 &a)%ra!&

+# % (l,,#&a)%ra!& &"#! & l),+& (r"$%r&r"& !" b,+l$%la& ,+(r)a#)"& $+ a&

(r&)ala#!,#a& " $+ ,#+"ra& 9%#*H"& &br" $#)ra),l,!a!" ! +&$%l l,& " +!%la*' !"

r"$"(*' !" &,#al hr+#al4 O& TG &' a 9r+a !" ar+a>"#a+"#) "#"r),$ +a,&

,+(r)a#)" # ra#,&+ "#%a#) & 9&9l,(!"& 9r+a+ a b,$a+a!a l,(!,$a "&)r%)%ra

b&,$a !a& +"+bra#a& $"l%lar"& " $l"&)"rl (r"$%r&r !&5 hr+#,& "&)"r,!"& !&

$,!& b,l,ar"& " !a -,)a+,#a D al+ !" )"r ,+(r)a#)"& 9%#*H"& #a& +"+bra#a& $"l%lar"&

,#9l%"#$,a#! a &%a 9l%,!"> " "&)a! !" a),-a*' !" "#>,+a& .C7AMPE ") al 200X/4

D"-,! J #a)%r">a h,!r9b,$a !& l,(!"& &"% +"$a#,&+ !" )ra#&(r)" "

!,&)r,b%,*' # (la&+a #' &"r,a (&&-"l &"+ al%+a 9r+a !" a!a()a*' h,!r9l,$a4 A&&,+

a& l,((r)"#a& .FIGURA 1/ &' r"&(#&-",& ("l )ra#&(r)" !" l,(!"& # &a#%"

"&("$,al+"#)" $l"&)"rl " TG $% +")abl,&+ "&) ,#),+a+"#)" r"la$,#a! $+ a

,#,$,a*' " (rr"&&' !a a)"r&$l"r&" .FRANSSEN ") al4 200 RADER ^ DAUG7ERT

200/4 E&)a& &' $#&),)%!a& (r %+ #$l" !" l,(!"& .)r,l,$"r!"& $l"&)"rl "&)"r,9,$a!

" -,)a+,#a& l,(&&l-",&/ " %+a $a+a!a ")"r#a !" 9&9l,(!"& " (r)"#a& .ALVARE_

LEITE ") al4 2003/ .FIGURA 1/4 D" a$r! $+ &%a r,"+ $+(&,*' !"#&,!a!" "

)a+a#h a& l,((r)"#a& (!"+ &"r $la&&,9,$a!a& "+5 %,l+$r#& l,((r)"#a& !" +%,)a

ba,a !"#&,!a!" .VLDL$/ l,((r)"#a& !" !"#&,!a!" ,#)"r+"!,r,a l,((r)"#a !" ba,a!"#&,!a!" .LDL$/ " l,((r)"#a& !" al)a !"#&,!a!" .7DL$/ .RADER ^ `ILSON 1QQ/

&"#! a& l,((r)"#a& LDL$ " 7DL$ a& +a,& ab%#!a#)"& # (la&+a .RADER ^

DAUG7ERT 200/4

A 9%#*' (r,#$,(al !a& l,((r)"#a& (la&+),$a& (ar"$" &"r )ra#&(r)" !&

)r,l,$"r!"& " ! $l"&)"rl !& l$a,& !" r,"+ ] # ,#)"&),# .r,"+ ""#a/ " #

9a! .r,"+ "#!"#a/ ] (ara & l$a,& !" ar+a>"#a+"#) " %),l,>a*' .SC7IAVO ") al4

2003/ .FIGURA 2a/4

16




Fi+,ra -5 E&%"+a "+ $r)" !" %+a l,((r)"#a4 F#)"5 CANTO .2011/4

.5. UILOMICRONS

O& @%,l+$r#& &' &,#)"),>a!& #a& $l%la& ! ,#)"&),# " )ra#&(r)a+ $l"&)"rl "

)r,l,$"r!"& (r-"#,"#)"& !a !,")a (ara 9a! " )"$,!& ("r,9r,$&4 S' a& +a,r"&

(ar)$%la& l,((r),$a& (r"&"#)"& # &a#%" $+ )"r (r)",$ r"la),-a+"#)" ba,4 A

(r,#$,(al a((r)"#a (r"&"#)" a B4 O 9a! !"(%ra & %,l+$r#& r"+a#"&$"#)"& !a

$,r$%la*' )ra#&9"r,#! al%#& !& $+(#"#)"& l,(!,$& (ara %)ra l,((r)"#a a VLDL$

.COSTAN_O 2011/ .FIGURA 2a/4 A !&a"+ !" @%,l+$r#& "+ "ral #' a$r"&$"#)a

,#9r+a*H"& r"l"-a#)"& #a +a,r,a !& $a&& #' &"#! (r)a#) r"al,>a!a r),#",ra+"#)"

("l& labra)r,& $l#,$& .III DIRETRI_ES BRASILEIRAS 2001 NCEP 2001/4

.50 4LDL#COLESTEROL

A l,((r)"#a !" +%,) ba,a !"#&,!a!" &,#)"),>a!a # 9a! " )ra#&(r)a

)r,l,$"r!"& " "+ +"#r ,#)"#&,!a!" $l"&)"rl (ara a& $l%la& a!,(&a& #!" &'

"&)$a!& % (ara )"$,!& +%&$%lar"& #!" (ar),$,(a+ ! +")abl,&+ $"l%lar .FIGURA

2b/4 A a((r)"#a (r"!+,#a#)" #"&)" $+(l" a B1004 Ta#) & %,l+$r#& %a#) a&

VLDL$ &9r"+ a a*' !" %+a "#>,+a (r"&"#)" # "#!)l, !"#+,#a!a l,(a&" l,((r),$a

a %al (r+-" h,!rl,&" !& )r,l,$"r!"& "ra#! $,!& ra& %" &' $a()a!& ("la&

$l%la&4

Para a)%ar "&)a "#>,+a r"%"r a (r"&"#*a !" ,#&%l,#a " !a a(l,((r)"#a CII "

9r)"+"#)" ,#,b,!a ("l& $,!& ra& %" 9%#$,#a $+ %+ +"$a#,&+ !" r")r17




al,+"#)a*' #"a),- .COSTAN_O 2011/4 E&)a l,((r)"#a )a+b+ #' !&a!a

r),#",ra+"#)" ("l& labra)r,& $l#,$& &"#! &%a $#$"#)ra*' "&),+a!a $#&,!"ra#!&"

%" "+ $#!,*H"& #r+a,& "%,-al" a %+ %,#) !a $#$"#)ra*' !& )r,l,$"r!"& %a#!

"&)" "(r"&& "+ +,l,ra+a& (r !"$,l,)r .NCEP 2001/4

.57 LDL#COLESTEROL

O& LDL$ 9r+a!& (r 9&9l,(!"& " )r,l,$"r!"& +a,& a& a((r)"#a& a(B &'

((%lar+"#)" $la&&,9,$a!a& $+ +a% $l"&)"rl4 E&)a& )+ a 9%#*' !" $arr"ar $l"&)"rl

$,r$%la#)" .)a#) !" r,"+ ""#a %a#) "#!"#a/ (ara )!& & )"$,!& "$") (ara

)"$,! h"(),$ .SPOSITO ") al4 200X/ .FIGURA 2b/4Para a $la&&,9,$a*' !a& $#$"#)ra*H"& !"&)a& l,((r)"#a& & -alr"& $#&,!"ra!&

!"&"-",& !"-"+ &"r +"#r"& %" 130 +;!L4 C#$"#)ra*H"& "#)r" 130 a 1Q +;!L &'

$#&,!"ra!& -alr"& l,+)r9"& %" ,#!,$a+ r,&$ !" a$+%l !" l,(!"& #& -a&&

&a#%#"&4 C#$"#)ra*H"& a$,+a !" 1Y0 +;!L &' $#&,!"ra!a& $+ al) r,&$ (ara

!"&"#-l-,+"#) !" !"#*a& $ar!,-a&$%lar"& &br")%! %a#! a&&$,a!a& a %)r& 9a)r"&

!" r,&$ .NCEP 2001/4

@%a#) +a,r"& a& $#$"#)ra*H"& !" l,((r)"#a& !" ba,a !"#&,!a!" +a,r )"+(!" ("r+a##$,a !"&)a& #a $rr"#)" &a#%#"a %" (!" 9a-r"$"r !"&"#-l-,+"#) !a

9r+a ,!a),-a !a& +"&+a&4 E&)a 9r+a ")r"+a+"#)" a)"r#,$a (r )"r +a,r 9a$,l,!a!"

a l,ar&" a& +a$r9a& " a& (ar"!"& !& -a&& .ANCE ") al4 2003/4

A& l,((r)"#a& !" ba,a !"#&,!a!" r"(r"&"#)a+ a(r,+a!a+"#)" !,& )"r*& !

$#)"! !" $l"&)"rl ! (la&+a " a,#!a )+ a 9%#*' !" &" l,ar a& r"$"()r"& !& )"$,!&

")rah"(),$& (ara 9r#"$,+"#) !" $l"&)"rl .SC7AEFER 2002/4 A("&ar ! ,+(r)a#)"

(a("l 9,&,l,$ !"&)a& l,((r)"#a& a "l"-a*' !" &%a& $#$"#)ra*H"& a$,+a !r"$+"#!a! "&) !,r")a+"#)" a&&$,a!a # (r#&),$ !" r,&$ !" a)"r&$l"r&" $r#ar,a#a4

.ANCE ") al4 2003/4

18




19

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Fi+,ra .5 M")abl,&+ !a& L,((r)",#a&5 a/ C,$l& ""# "#!"# " )ra#&(r)" r"-"r&4 b/ M")abl,&+

h"(),$ !a& l,((r)"#a&4 F#)"5II CONSENSO BRASILEIRO SOBRE DISLIPIDEMIAS .1QQY/4

.58 DL#COLESTEROL

O& 7DL$ &' $+(&)& 9r+a!& ("la %#,' !" 9&9l,(!"& )r,l,$"r!"& "

a((r)"#a& a(A ((%lar+"#)" !"#+,#a!a& b+ $l"&)"rl $#&),)%"+ !" 20 a 30 !

$l"&)"rl ))al "+ ,#!,-!%& #r+a,& .LIMA GLANER 200Y/4 Al+ !a ,+(r)a#)" 9%#*'

!" $arr"ar $l"&)"rl $,r$%la#)" (ara 9a! 7DL$ )a+b+ $#)r,b%, (ara a (r)"*'

! l",) -a&$%lar $#)ra a a)"r#"&" !"-,! J r"+*' !" l,(!"& ,!a!& !a&

l,((r)"#a& !" ba,a !"#&,!a!" ,#,b,*' !a 9,a*' !" +l$%la& !" a!"&' " +#$,)& a

"#!)l, " "&),+%la*' !a l,b"ra*' !" ,! #)r,$ .SPOSITO ") al4 200X/4

C#$"#)ra*H"& !" l,((r)"#a& !" al)a !"#&,!a!" +"#r"& ! %" 3 +;!L (ara

h+"#& " +;!L (ara +%lh"r"& (r(,$,a+ %+ al) r,&$ (ara a !"(&,*' !" l,(!"& "

+#$,)& #a& (ar"!"& !& -a&& &a#%#"& (r #' $#&"%,r"+ )ra#&(r)ar %+a

%a#),!a!" &%9,$,"#)" !" $l"&)"rl (ara 9a! #!" "&)" +")abl,>a!4 A&&,+

$#$"#)ra*H"& a$,+a !"&)"& -alr"& "&)ab"l"$,!& (ara h+"#& " +%lh"r"& &' $#&,!"ra!a&

$+ !"&"-",& .NCEP 2001/4

U+a ba,a $#$"#)ra*' !" l,((r)"#a& !" al)a !"#&,!a!" & $#&,!"ra!a $+

r"al+"#)" (r"$%(a#)" %a#! a$+(a#ha!a !" "l"-a!a& $#$"#)ra*H"& !" l,((r)"#a& !"

ba,a !"#&,!a!" " !" )r,l,$r,!"& .SPOSITO ") al4 200X/4 @%a#) +a,r )"+( !"!




("r+a##$,a !"&)" !"&"%,lbr, +a,r"& a& $ha#$"& !" !"&"#-l-,+"#) !" a)"r&$l"r&"

.ANCE ") al4 2003/4

.59 TRIGLICERIDEOS

O& l,(!"& &' ar+a>"#a!& #a 9r+a !" )r,l,$"r!"& +l$%la& !" )r& $,!&

ra& .&a)%ra!& +#&&a)%ra!& % (l,,#&a)%ra!&/ a$(la!& a %+ l$l .l,$"rl/ (ara

$#&),)%r"+ r"&"r-a& !" "#"r,a4 D"("#!"#! !a &%a r,"+ (!"+ &"r $la&&,9,$a!& $+

"#!"# .&,#)"),>a! ("l (r(r, ra#,&+/ % ""# .(r-"#,"#)" !a al,+"#)a*'/

&"#! a r,"+ ""#a a %" r"(r"&"#)a a(r,+a!a+"#)" 0 !& %,l+$r#& $,r$%la#)"&

# &a#%" .LE7NINGER ") al 1QQ BANES 2000 MOTTA 2003/4 O& )r,l,$"r!"&""#& !"(&,)a+&" # )"$,! a!,(& #%+ (r$"&& %" !%ra a) Yh a(& a 9r+a*' !

%,l+$r#4 O& )r,l,$"r!"& "#!"#& &' &,#)"),>a!& ("l 9a! " )ra#&(r)a!& (r

VLDL$4 A &#)"&" " )ra#&(r)" !" )r,l,$"r!"& "#!"#& &' r"la),-a+"#)" ,#!"("#!"#)"&

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al4 200/4

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D"&,#a+&" !,&l,(,!"+,a& % h,("rl,(,!"+,a& a& "l"-a*H"& &r,$a& !" %+ % +a,&

$+(#"#)"& &a#%#"& !"$rr"#)"& !" !,&)rb,& "+ %al%"r 9a&" ! +")abl,&+ l,(!,$.C7ACRA ") al4 200/4 E&)" "$"&& (!" l"-ar a a$+%l ,#)ra$"l%lar !" l,(!"& "

!"(&,*' !& +"&+& "+ -a&& " )"$,!& "ra#! a%+"#) ! r,&$ $ar!,-a&$%lar % a)

+"&+ (a)l,a& )a,& $+5 a)"r&$l"r&" ,#9ar) a%! ! +,$r!, "&)"a)&" h"(),$a

b"&,!a!" D,ab")"& M"ll,)%& T,( II "#)r" %)ra& .FIL7O 2000/4

A $#$"#)ra*' (la&+),$a "l"-a!a !" LDL$ )"+ r"la*' !,r")a $+

!"&"#-l-,+"#) !" !"#*a ar)"r,al $r#ar,a#a " a ba,a $#$"#)ra*' (la&+),$a !" 7DL$

)+ &,! a(#)a!a& $+ %+ !& +a,& 9r)"& 9a)r"& !" r,&$ ,#!"("#!"#)"& (ara a !"#*a

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PENALVA ") al4 200 COEL7O ") al4 200 FRANCA ") al4 200Y/4

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+r)al,!a!" (r !"#*a& $ar!,-a&$%lar"& .DCV/ r"(r"&"#)a#! #a +a,r,a !& (a&"& "#)r"

30 a 3 !" )!a& a& $a%&a& !" b,)4 ? # Bra&,l &"%#! a DATASUS "+ 2010

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$#&"%#$,a !" !"#*a& ! a(ar"lh $,r$%la)r, .STEFANINI =ASINS=I " CARVAL7O200/4

A a)"r&$l"r&" %+ (r$"&& +%l),9a)r,al (rr"&&,- " l"#) # %al h al)"ra*'

#a (ar"!" ar)"r,al .GOTTLIEB ") al4 200/4 A #"&" !a 9r+a*' !a (la$a !" a)"r+a

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I!"#),9,$ar a $rr#$,a !" (&&-",& !,&l,(,!"+,a&4

"




75 METODOLOGIA

75- AMOSTRAGEM

A ("&%,&a 9, &%b+"),!a J Plataforma Brasil (ara &"r !,r"$,#a! a C+,) !" \),$a

"+ P"&%,&a $+ S"r"& 7%+a#& " a&&,+ a)"#!"#! a& #r+a& ! C#&"lh Na$,#al !"

Sa!" (r"-,&)a& #a r"&l%*' 1QY;QY ! C#&"lh Na$,#al !" Sa!" M,#,&)r, !a Sa!"4O (r"&"#)" "&)%! 9, a(r-a! ("l C+,) !" \),$a "+ P"&%,&a "+ S"r"& 7%+a#&

! I#&),)%) !" M"!,$,#a I#)"ral Pr94 F"r#a#! F,%",ra .IMIP/ a)ra-& ! (r$"&& #

3113 $#9r+" a& !,r")r,>"& " #r+a& r"%la+"#)a!ra& !" ("&%,&a "#-l-"#! &"r"&

h%+a#&4

E&)%! !" $a+( %a#),)a),- " !"&$r,),- r"al,>a! $+ a ((%la*' r"&,!"#)" #a

_#a !a Ma)a Nr)" !" P"r#a+b%$4 O "&)%! 9, r"al,>a! #& +%#,$(,& !" T,+baba

F"rr",r& Ca+%)a#a " Al,a#*a4

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A ((%la*' $#&,!"ra!a (ara "&)%! 9, $#&),)%!a (r (a$,"#)"& #a 9a,a ")r,a !"

0 a#& "+ !,a#)" %&%r,& ! S,&)"+a #,$ !" Sa!" .SUS/ " !a r"!" (ar),$%lar #&

r"9"r,!& +%#,$(,& ))al,>a#! Q1 ,#!,-!%&4

O& -alr"& !" r"9"r#$,a (ara LDL$ " 7DL$ "&)' !"&$r,)& #a Tab"la 14

Ta/ea -5 Valr"& !" r"9"r#$,a !& l,(!"& (ara ,#!,-!%& a$,+a !& 20 a#& !" ,!a!"4

F#)"5 III D,r")r,>"& Bra&,l",ra& &br" D,&l,(,!"+,a& " D,r")r,> !" Pr"-"#*' !a A)"r&$l"r&" ! D"(ar)a+"#)!" A)"r&$l"r&" !a S$,"!a!" Bra&,l",ra !" Car!,l,a 20014

75. CRITÉRIOS DE INCLUSÃO

D,")a hab,)%al " ("& "&)-"l ("l +"#& !%a& &"+a#a& a#)"& !a $l")a

?"%+ !" 12 a 1 hra& r"(%& (r-, &"#)a! ("l +"#& $,#$ +,#%)& a#)"& !a $l")a

N' )"r (ra),$a! ""r$$,& -,r&&

N' )"r ,#"r,! b"b,!a& al$l,$a& #a -&("ra !a $l")a

T"r r"al,>a! "a+" labra)r,al #& l),+& Y +"&"&4

750 CRITÉRIOS DE E?CLUSÃO

7,("rl,(,!"+,a &"$%#!r,a a&&$,a!a $+ !"#*a r"#al h"(),$a % ),r",!,a#a !,ab")"& "

h,&)r,a 9a+,l,ar !" !,ab")"& % !"#*a ar)"r,al $r#ar,a#a4

757 COLETA DE DADOS

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O& Da!& 9ra+ $l")a!& # ("r! !" N-"+br !" 2012 a ?a#",r !" 2013 a

(ar),r ! $a!a&)r !" "#)ra!a !& (a$,"#)"& r"&,!"#)"& #a r",' !" "&)%!4

#.$AN1LISE LABORATORIAL

O& (r$"&&& a#al),$& 9ra+ r"al,>a!& # Labra)r, !" A#l,&"& Cl#,$a& @UALI

LAB .T,+baba PE/ "+ a+&)ra& !" &a#%" . +L/ $l")a!a& "+ )%b& Vacutainer " &r

9, &"(ara! !a& h"+$,a& (r $"#)r,9%a*' (ara a !&a"+ !" $l"&)"rl 7DL4 A !&a"+

"#>,+),$a !" 7DL$ 9, (r"$"!,!a ("la (r"$,(,)a*' !" LDL$ (r"&"#)" #& &r& +"!,a#)"

%& !" r"a"#)"& r"&(#&,-& J &"(ara*' +a#),$a $#)"#! &%l9a) !" !")ra# " $lr") !"

+a#&, . Katal /4 A !")"r+,#a*' !" LDL$ (ara TG &r,$ aba, !" 00+;!l 9, b),!a ("l $l$%l !" Fr,"!"al!5 LDL$ W CT c 7DL$ c TG; .A#!r,l A 2000 III D,r")r,>"&

Bra&,l",ra& Sbr" D,&l,(,!"+,a& " D,r")r,> !" Pr"-"#*' !a A)"r&$l"r&" ! D"(ar)a+"#) !"

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759 AN1LISE DOS DADOS

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! ("r9,l l,((r)",$4 Para a a#l,&" "&)a)&),$a 9, %),l,>a! T"&)" !" P"ar&# a)ra-& !

&9)ar" Gra(hPa! Pr,&+ .-"r&' 40/4

6




85 RESULTADOS

A r",' !a Ma)a Nr)" ! "&)a! !" P"r#a+b%$ $+(r""#!" 1Q +%#,$(,& !"#)r"

& %a,& %a)r 9ra+ b") ! "&)%! .Al,a#*a Ca+%)a#a F"rr",r& " T,+baba/4 N'

h%-" #"#h%+ (rbl"+a )$#,$ "#)r" )!a& a& Q1 a+&)ra& &a#%#"a&4 A +"!,a#a !" ,!a!"

9, !" Q a#& ha-"#! !,9"r"#*a& !a +"&+a "+ r"la*' a &" .7+"+ W X M%lh"r W

Y0/4 Na Tab"la 2 a(r"&"#)a!a a $ara$)"r,>a*' !a a+&)ra "&)%!a!a4 E#)r" & (a$,"#)"&,#$l%!& # "&)%! a +a,r (ar)" 9, ! &" 9"+,#,# .X23/4

Ta/ea .4 D,&)r,b%,*' !a a+&)ra !& r"&,!"#)"& !a Ma)a Nr)" ! "&)a! !" P"r#a+b%$4

N

Seo

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7




0 a Y0 Q 3

d Y0 2 Y1

A& (r"-al#$,a& !" al)"ra*H"& #a& !,9"r"#)"& )aa& ! ("r9,l l,((r)",$ "&)'

a(r"&"#)a!a& # Gr9,$ 14

C#&,!"ra#! $+ !,&l,(,!+,$ (a$,"#)" $+ al)"ra*' "+ ("l +"#& %+a !a&

9ra*H"& ! ("r9,l l,((r)",$ a(r,+a!a+"#)" a +")a!" !& (ar),$,(a#)"& .0/

"#%a!r%&" $+ (r)a!r"& !"&&a (a)l,a4 O,) (a$,"#)"& a(r"&"#)ara+ al)"ra*H"& #a&

!%a& 9ra*H"& l,((r)",$a& " (r ,&& #' 9ra+ "#%a!ra!& # $l$%l &%(ra$,)a!4

A 9ra*' 7DL$ b&"r-%&" al)"ra!a "+ 33 (a$,"#)"& !,9"r"#)"+"#)" !a LDL$ %"

"&)"-" al)"ra!a "+ a("#a& 1Q (a$,"#)"& &"#! a !,9"r"#*a "#)r" "la& !" a(r,+a!a+"#)"14

Gr23i$o -5 P"r9,l l,((r)",$ #& r"&,!"#)"& !a Ma)a Nr)" ! "&)a! !" P"r#a+b%$ &"%#! & -alr"&

r"$+"#!a!& ("la III D,r")r,>"& Bra&,l",ra& &br" !,&l,(,!"+,a&4

Na Tab"la 3 &' "(r"&&a& a& $+(ara*H"& !a& l,((r)"#a& "#)r" & #"r& " a

,!a!" !& (a$,"#)"&4

A& $#$"#)ra*H"& !a& l,((r)"#a& (ra),$a+"#)" #' !,9"r,ra+ "+ r"la*' a &"

(ara (arK+")r 7DL$4 E+ r"la*' a LDL$ ,#!,-!%& ! &" 9"+,#,# a(r"&"#)ara+

-alr"& +a,& "l"-a!& .±DP W Q3/4 E#)r" & h+"#& -alr +,+ "#$#)ra! !" LDL$

9, !" 1XY +;!L "#%a#) %" #a& +%lh"r"& 9, !" 23Y +;!L4

8




Ta/ea 05 N-",& !" 7DL$ " LDL$ &"%#! &" #& r"&,!"#)"& !a Ma)a Nr)" ! "&)a! !" P"r#a+b%$4

DL#$+*H

LDL#$+*H

Seo n M*ia ±DP n M*ia ±DP

Ma&$%l,# 2 Y 11 2 102 3XQ2

F"+,#,# YY 13 11 YY 121 Q3

Tota Q1 X13 13 Q1 11X32 X1

O& Gr9,$& 2 " 3 r"(r"&"#)a+ a r"la*' "#)r" & #-",& !" 7DL$ " LDL$ $+

a-a#* !a ,!a!" !& (a$,"#)"& r"&("$),-a+"#)"4

R 2

W 0001 8 W 0021 e 33YX #!" R 2

W $"9,$,"#)" !" $rr"la*' !" P"ar&# 8 W "%a*' !a r")a4

Gr23i$o .& R"la*' "#)r" $#$"#)ra*' !" 7DL$ " ,!a!" #& r"&,!"#)"& !a Ma)a Nr)" ! "&)a! !"P"r#a+b%$4

9




R 2 W 00Q 8 W 1Y13 e 21X32 #!" R 2 W $"9,$,"#)" !" $rr"la*' !" P"ar&# 8 W "%a*' !a r")a4

Gr23i$o 0& R"la*' "#)r" $#$"#)ra*' !" LDL$ " ,!a!" #& r"&,!"#)"& !a Ma)a Nr)" ! "&)a! !"P"r#a+b%$4

C+ (!" &"r b&"r-a!a a !,&)r,b%,*' !" a+b& 9, +%,) !,&("r&a al+ !" #' )"r

&,! -"r,9,$a!a al)"ra*' &,#,9,$a),-a !& #-",& !" 7DL$ .R 2 W 0001/ " )a+(%$ !"

LDL$ .R 2 W 00Q/ $+ "#-"lh"$,+"#)4 Ta,& a$ha!& #' ("r+,)"+ a9,r+ar % #"ar a

,#9l%#$,a !a ,!a!" #a al)"ra*' !& #-",& !a& r"9"r,!a& l,((r)"#a&4

6. DISCUSSÃO

7 al%+ )"+( a& %"&)H"& r"la$,#a!a& J& +%!a#*a& 9,&,l,$a& " J& !"#*a&

)(,$a& ! "#-"lh"$,+"#) )+ !"&("r)a! (r"$%(a*' #a $+%#,!a!" $,"#)9,$a4 C+ ,&&

"&)%!& )+ &,! r"al,>a!& $+ ("&&a& !" ,!a!" a-a#*a!a " ,!&& "+ )! +%#!

abr!a#! !,9"r"#)"& %"&)H"& r"la$,#a!a& J -"lh,$" a ""+(l ! ("r9,l l,(!,$ r"la$,#a!

a "&),l !" -,!a )"+a& ("&%,&a!& "+ !,9"r"#)"& (a&"& .CURB ") al4 200 MILIONIS ")

al4 200Y CASLA=E ") al4 2010/ $+ $a& ! Bra&,l .G%"!"& " G%"!"& 1QQFREITAS ") al4 200Q/4

N"&)" "&)%! a("&ar !" %+ r"!%>,! "&(a* a+&)ral 9, -"r,9,$a!a (r"!+,#K#$,a !"

(a$,"#)"& ! &" 9"+,#,# .X23/4 R"&%l)a! &"+"lha#)" 9, "#$#)ra! "+ %)ra&

("&%,&a& r"al,>a!a& # Bra&,l .FERREIRA ") al4 2010/4 Fa) %" (!" &"r a)r,b%! J +a,r

"("$)a),-a !" -,!a "#)r" a& +%lh"r"& " J +a,r )aa !" +r)al,!a!" "#)r" & h+"#& -"#&

& %a,& &' +a,& "(&)& a a$,!"#)"& !" )rabalh a "),l,&+ a )aba,&+ J +r)" (r

$a%&a& ")"r#a& !"#*a& $ar!,-a&$%lar"& " #"(la&,a& .VERAS 200/4

"!




S"%#! ,#9r+a*H"& !a Ora#,>a*' M%#!,al !" Sa!" a& +%lh"r"& -,-"+ +a,& #a

+a,r,a !& l%ar"& r"&%l)a#! "+ %+a +a,r (r(r*' !" +%lh"r"& "+ r"la*' a& h+"#&

"+ r%(& ")r,& +a,& -"lh&4 7 %+a )"#!#$,a !" +a,r l#"-,!a!" "#)r" a& +%lh"r"& %"

"#)r" & h+"#& "+ ,!a!" +a,& a-a#*a!a ("r! "+ %" a& !"9,$,#$,a& " & (rbl"+a& !"

&a!" +a,& &" +a#,9"&)a+ .`7O 200/4

A +a,r (r(r*' !" +%lh"r"& "#$#)ra!a #"&)" "&)%! $#9,r+a 9"#+"#

$#h"$,! (r 9"+,#,>a*' !a -"lh,$" .`7O 200 SALGADO 2002 CAMARANO

200Y/4 S"%#! P"r",ra ") al4 .200/ "&&" 9"#+"# (!" &"r "(l,$a! (r 9a)r"& b,l,$&

" &$,$%l)%ra,&4 N "#)a#) (r"!+#, !" +%lh"r"& "+ r"la*' a& h+"#& #a r",' !a

Ma)a Nr)" !" P"r#a+b%$ " a +a,r "("$)a),-a !" -,!a #' &,#,9,$a+ %al,!a!" !" -,!a

(ara "&)a& ,!&a&4@%a#) a 7DL$ a +!,a "#)r" a& +%lh"r"& !"&)" "&)%! 9, 13 +;!L " "#)r" &

h+"#& 9, Y +;!L4 E+ "&)%! realizado $+ a!%l)& " ,!&& # +%#,$(, !" Ca+(&

!& G8)a$a>"&;R? -"r,9,$%&" %" & #-",& !" 7DL$ 9ra+ &%("r,r"& "#)r" & h+"#&

,!&& .SOU_A ") al4 2003/4 A("&ar !a !,9"r"#*a "#$#)ra!a (ara & -alr"& !a +!,a "#)r"

& &"& #"&)" "&)%! a& +%lh"r"& #r+al+"#)" a(r"&"#)a+ #-",& !" 7DL$ +a,& "l"-a!&

%" & h+"#& " (r ,&& & -alr"& r"$+"#!a!& $+ !"&"-",& (ara 7DL$ -ar,a "#)r"

& &"& .PO__AN 200/4O -alr +!, al)"ra! !" 7DL$ .31 +;!L/ "#$#)ra! "#)r" a& +%lh"r"& !"&)"

"&)%! "-,!"#$,a a #"$"&&,!a!" !" -,,lK#$,a !" 9a)r"& !" r,&$ %+a -"> %" #-",& !" 7DL

$ ,#9"r,r"& a 0 +;!L (a&&a+ a &"r 9a)r !" r,&$ ,#!"("#!"#)" (ara !"#*a ar)"r,al

$r#ar,a#a "#)r" +%lh"r"& "+ "&("$,al "#)r" 0 " YQ a#& .SBC 200/4 N-",& !"

)r,l,$r,!"& +a,r"& % ,%a,& a 10 +;!L " 7DL$ +"#r"& % ,%a,& a 0 +;!L &'

$+(#"#)"& !a !,&l,(,!"+,a %" $ara$)"r,>a a &#!r+" +")abl,$a a(r"&"#)a#! +a,r

,+(a$) #a ,#$,!#$,a !" !"#*a $ar!,-a&$%lar "+ +%lh"r"& ! %" "+ h+"#&"&("$,al+"#)" a%"la& #a 9a&" !" +"#(a%&a .GRAVINA ") al4 2010/4

Ta#) "+ +%lh"r"& %a#) #& h+"#& !"&)" "&)%! #' 9, b&"r-a!a $rr"la*'

"&)a)&),$a &,#,9,$a),-a #& #-",& !" 7DL$ $+ a-a#* !a ,!a!"4 N "#)a#) S%>a ") al4

.2003/ -"r,9,$ara+ +!,a& !" 7DL$ "#)r" a& +%lh"r"& ,#9"r,r"& a 0 +;!L a (ar),r !& Y0

a#& r"la$,#a#!&" !,r")a+"#)" $+ a%+"#) ! r,&$ !" !"#*a $r#ar,a#a4

7 $#)r-r&,a& &br" a& +%!a#*a& #& #-",& !" 7DL$ $+ a-a#* !a ,!a!"4

Al%#& "&)%!& )ra#&-"r&a,& .CARROLL ") al4 200/ " l#,)%!,#a,& .CURB ") al4 200/

b&"r-ara+ %" #' $rr"+ +%!a#*a& #& #-",& !" 7DL$ "+ h+"#&4 N NHANES Study

"1




.CARROLL ") al4 200/ #' 9, b&"r-a!a al)"ra*' !" 7DL$ &,#,9,$a),-a "#)r" &

h+"#& +a& "#)r" a& +%lh"r"& h%-" %+ a%+"#) ! 7DL$ "#)r" & Y0 " X a#&4 O%)r&

"&)%!& -"r,9,$ara+ &,#,9,$a),- a%+"#) a (ar),r !" 0 a#& # "#)a#) al%#& 9a)r"&

(!"+ ,#9l%"#$,ar #a -ar,a*' !& #-",& !" 7DL$ a ""+(l !a& +%!a#*a& #& "&),l& !"

-,!a " #& hb,)& al,+"#)ar"& .UPMEIER ") al4 2011 INGELSSON ") al4 200Q/4

@%a#) a LDL$ 9, -"r,9,$a! #"&)" "&)%! +a,r +!,a "#)r" a& +%lh"r"& .121

+;!L/ %" "#)r" & h+"#& .102 +;!L/ $+ !,9"r"#*a4 Da! &"+"lha#)" 9, -"r,9,$a!

(r S%>a ") al4 .2003/ a $+(arar & -alr"& +!,& !" LDL$ "#)r" h+"#& " +%lh"r"&4

E#)r")a#) +"&+ & -alr"& !" LDL$ "#$#)ra!& #"&)" "&)%! &"#! &%("r,r"& %a#!

$+(ara!& $+ %)r& r"&%l)a!& "&)"& ,!&& "&)' $+ & #-",& !"#)r ! !"&"-"l %+a

-"> %" -alr r"$+"#!a! (ara LDL$ !"-" &"r +"#r %" 1Y0 +;!L .SPOSITO ") al4200X/4

O LDL$ "&) ,#),+a+"#)" r"la$,#a! $+ a 9r+a*' !a (la$a a)"r&$l"r),$a4 E&&a&

(ar)$%la& a ("#")rar"+ #a $a+a!a #),+a !a ar)r,a (a&&a+ (r (r$"&& !" ,!a*'4 O

LDL$ ,!a! al)"ra a 9%#*' ! "#!)l, a%+"#)a#! a -%l#"rab,l,!a!" ! -a& (ara a

9r+a*' !a (la$a a)"r&$l"r),$a4 N' h %+ $#&"#& &" & ,!&& &' +a,& -%l#"r-",& %"

& -"#& +a& &" &ab" %" -r,& 9a)r"& !" r,&$ %" &" a$%+%la+ a l# !& a#& (!"+

&" a&&$,ar " ,#9l%"#$,ar #a (r"!,&(&,*' (ara &%r,+"#) !a a)"r&$l"r&" .LIMA "FONOLLOSA 2003/4

E#)r" & r%(& ")r,& & #-",& !" LDL$ $#),#%ara+ &%("r,r"& "#)r" a& +%lh"r"&4

F, -"r,9,$a! (r S%>a ") al4 %" #-",& !" LDL$ +&)rara+&" &,#,9,$a),-a+"#)"

&%("r,r"& "#)r" a& +%lh"r"& "+ )!& & r%(& ")r,&4 Da!& ! NHANES Study +&)ra+

%" h+"#& $+ ,!a!" "#)r" 30 " Q a#& a(r"&"#)ara+ #-",& +!,& !" LDL$ +a,r"& %"

& !a& +%lh"r"& !" +"&+a ,!a!" +a& # r%( $+ X0 a#& % +a,& a& +%lh"r"&

a(r"&"#)ara+ +a,r +!,a !" LDL$ %" & h+"#&4 N Turku Elderly Study .UPMEIER ")al4 2011/ , 9ra+ "#$#)ra!& -alr"& &,#,9,$a),-a+"#)" +a,r"& !" LDL$ "+ +%lh"r"&

,!&a& #a& )r& a-al,a*H"& r"al,>a!a& a l# !" 1 a#& !" &"%,+"#)4

O& a$ha!& !"&)" "&)%! a(r"&"#)a+ al%+a& l,+,)a*H"& $+ #+"r r"la),-a+"#)"

("%"# !" (a$,"#)"& "a+,#a!& $+(ara! $+ %)r& "&)%!& " a a%&#$,a !" %+

%"&),#r, &$,"$#+,$$%l)%ra4 A a-al,a*' !& LDL$ " 7DL$ &>,#h& #'

&%9,$,"#)" (ara (r"&%+,r $+ $"r)">a %+a (&&-"l D"#*a Ar)"r,al Cr#ar,a#a4

D,a#)" !a& b&"r-a*H"& "(&)a& 9a>&" #"$"&&r, a(r9%#!ar "&&" "&)%! a)ra-& !"

%+ l"-a#)a+"#) !" %)ra& -ar,-",& %" (!"+ "&)ar a,#! (ara %" "&)"a+ ,#&)ala!&

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"&&"& #-",& !" !,&l,(,!"+,a& # &" 9"+,#,# )a,& $+5 hb,)& al,+"#)ar"& &br"("&

&"!"#)ar,&+ )aba,&+ %& !" l$l +"!,$a+"#)& &)r"&& %"&)H"& a9"),-a& ")$4 &"#!

,&& b") !" 9%)%ra& ("&%,&a&4

:5 CONCLUS;ES

A& !"#*a& $ar!,-a&$%lar"& r"(r"&"#)a+ %+ ra#!" (rbl"+a !" &a!" (bl,$a #

Bra&,l #"ra#! $%&)& # a)"#!,+"#) " #a& ba,a& h&(,)alar"&4 D"-"&" (r)a#)

,#)"#&,9,$ar "&9r*& #a !")"$*' (r"$$" (r"-"#*' " #a "!%$a*' "+ &a!" (ara +,#,+,>ar

"&&"& ara-& %" )a#) $a%&a+ (r"%>& J %al,!a!" !" -,!a !a ((%la*'4

O& !a!& a%, a(r"&"#)a!& al"r)a+ (ara a #"$"&&,!a!" !" ,#$"#),- J& +"!,!a& !"

"&),l !" -,!a &a%!-"l #a r"9"r,!a ((%la*' (r,#$,(al+"#)" # %" !,> r"&(",) J (r),$a !"a),-,!a!" 9&,$a " a hb,)& al,+"#)ar"& &a%!-",&4

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<5 REFER=NCIAS

ALVARE_LEITE ?4I4 OLIVEIRA D4R4 PELU_IO M4C4G4 D,&l,(,!"+,a&4 I#5 NETO F4T4.E!4/ N%)r,*' Cl#,$a4 R, !" ?a#",r5 G%a#abara =a# (41QY211 20034

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BANES DOMINIC_A=4 B,%+,$a M!,$a4 14 "!4 S' Pa%l5 Ma#l" (4 YY 20004

CAMARANO AA4 E#-"lh"$,+"#) !a ((%la*' bra&,l",ra5 %+a $#)r,b%,*' !"+r9,$a4I#5 Fr",)a& EV ") al4 Tra)a! !" G"r,a)r,a " G"r#)l,a4 24 "!4 R, !" ?a#",r5 G%a#abara=a# (4 10 200Y4

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CASLA=E M? PAC=ARDA C? ROBERTSONB M COONEA ? NELSONC ?? FORDBI ") al4 L,((r)",#a&&$,a)"! (h&(hl,(a&" A ,#9la++a)r8 b,+ar6"r& a#! r,&6 9 $ar!,-a&$%lar !,&"a&" ,# )h" Pr&("$),-" S)%!8 9 Pra-a&)&),# ,# )h" El!"rl8 a) R,&6 .PROSPER/4 A)h"r&$l"r&,&4 2105 23 20104

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LE7NINGER ALBERT L4 NELSON DAVID L4 CO< MIC7AEL M4 Pr,#$(,& !"B,%+,$a4 24 "!4 S' Pa%l5 Sar-,"r 1QQ4

LIMA ? FONOLLOSA V VILARDELL M4 A)"r#"&,&4 Fa$)r"& !" r,"& $ar!,-a&$%lar "# "l a#$,a#4 R"- M%l) G"r#)l4 13.3/5 1YY0 20034

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MARTINE_ TiNIA LEME DA ROC7A VALE ANDR\IA LOURES4 A)"r&$l"r&"")ra$r#r,a5 E),l,a R"la*' $+ a $r#ar,(a),a& " "&)ra),a& # )ra)a+"#)4 R"-,&)aS$,"!a!" !" Car!,l,a ! E&)a! !" S' Pa%l4 Vl4 10 #j Y N-;D"> 2000 (424

MAR__OCO ANITA TORRES BAARDO BAPTISTA4 B,%+,$a B&,$a4 24 "!4 R, !"?a#",r5 G%a#abara =a# 1QQQ4

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