Michele Final

7/21/2019 Michele Final

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UNIVERSIDADE ESTADUAL DO CEARÁ

MICHELLE GERMANO CYSNE CARNEIRO

DETERMINAÇÃO DA COMPOSIÇÃO CENTESIMAL ETEORES DE CAROTENÓIDES, ANTOCIANINAS E

FLAVONÓIDES DO FRUTO NONI (Morinda citrifolia L.)

EM PLANTAS CULTIVADAS EM FORTALEZA - CE.

FORTALEZA – CEARÁ

!!"




DETERMINAÇÃO DA COMPOSIÇÃO CENTESIMAL ETEORES DE CAROTENÓIDES, ANTOCIANINAS E

FLAVONÓIDES DO FRUTO NONI (Morinda citrifolia L.)

EM PLANTAS CULTIVADAS EM FORTALEZA - CE.

M#$#%&'' '*&++$'' '# C/&# + N/&01#' U$2+&'+ E'/'3 # C+'&4, 5#6#&+7/# *'&5'3 *'&' #8+$01# + %&'/ +9'5:'&+3 +6 N/&01#.

O&+$'#&'; P&#< D&< M'&' I='8+3 F3#&$#

G/++.

FORTALEZA – CEARÁ

!!"




DETERMINAÇÃO DA COMPOSIÇÃO CENTESIMAL E TEORES DE

CAROTENÓIDES, ANTOCIANINAS E FLAVONÓIDES DO FRUTO NONI (Morinda

citrifolia L.) EM PLANTAS CULTIVADAS EM FORTALEZA - CE.

M#$#%&'' '*&++$'' '# C/&# + N/&01#' U$2+&'+ E'/'3 # C+'&4, 5#6#&+7/# *'&5'3 *'&' #8+$01# + %&'/ +9'5:'&+3 +6 N/&01#.

A*&#2'# +6; >?@!@!!"

9ANCA EBAMINADORA

P&#<. D&'. M'&' I='8+3 F3#&$# G/++

U$2+&'+ E'/'3 # C+'&4

O&+$'#&'

P&#. LD A$$# + P4/' V'3+$0' ' S32'

U$2+&'+ E'/'3 # C+'&4

P&#<. M.S5. N'' M'&' A%&' D$=

U$2+&'+ E'/'3 # C+'&4



DEDICATÓRIA

D+5# ++ &'8'3:# 6$:' '63', 7/+

'&'2 + +/ +$$'6+$# + '85'01#

6+ += '5&+'& $' 6*#&$5' '

+/5'01#, '36 + 6+ '=+& 5&+5+&

6#&'36+$+ + $+3+5/'36+$+.



AGRADECIMENTOS

A%&'+0# ' D+/ *#& 6+ '& #&0' *'&' /*+&'& # #845/3# + 6+ *+&6&

'*&+$+& + 5&+5+& 5'' 2+= 6'J

A# 6+/ $'6#&'# 9&/$#, 7/+ '$# 6+ '*##/ +6#5#$'36+$+ + 6+ '/#/ $'

+3'8#&'01# ++ &'8'3:#J

A# 6+/ '6%# 7/+ 6+ '*#'&'6 + 5#6*&++$+&'6 # 6#2# ' 6$:' '/K$5'

+6 24&# 6#6+$# + 5#$&'+&$='01#.

*&#+#&' D&'. M'&' I='8+3 F3#&$# G/++, *+3' /' *'5K$5' + /' +5+3+$+

#&+$'01# /&'$+ #' ' '+ ++ &'8'3:# + *+3# +/ 8&3:'$6# +

+5'01# ' ## # +/ *&#+#J

*&#+#&' V$' M'%'3:1+ M#$+$+%&# + '# *&#+#& 5'&# G/61#, *+3'

5#3'8#&'01# $' &+'3='01# + *'&+ # +*+&6+$# +6 +/ &+*+52#

3'8#&'&#J

*&#+#&' N'' M'&' A%&' D$= *+3' /' /%++ + *+3# &/#

%+$36+$+ #&$+5# *'&' ' &+'3='01# # +*+&6+$#J

A# *&#+#& A$$# + P4/' V'3+$0' ' S32' *#& '5+'& '=+& *'&+ ' 8'$5'

+'6$'#&'J

A# 8#3' + '# *&#+#&+ # L'8#&'&# + 9#7/65' H/6'$' ' UECE,

+6 +*+5'3 '# R6/3# A3# + O32+&' C'&#, *+3' /' 5#3'8#&'01# $' 6'#& *'&+

# +*+&6+$#, *# +6 +3+ # +/# $1# +&' # *#2+3.



RESUMO

E' 6#$#%&'', &+'3='' +6 F#&'3+=', C+'&4, $# *+&## + #//8&# + !!Q ' '8&3 +

!!", +2+ 5#6# #8+# + +/# # &/# $#$ (Morinda citrifolia L.), $'2# # /#++ '

Á', 7/+ +6 # /3='# :4 6' + # 63 '$# $' P#3$' 5#6 2+&# $

+&'*K/5#. S/' '2'+ 1# '&8/' '# +/ 5#6*#$+$+, *&$5*'36+$+

+&#$$', /6 '35'3+. D+2# /3='01# # $#$ $# 9&'3 + $# 6/$# 5#6 $'3'+

+&'*K/5' + $/&5#$', # *&++$+ &'8'3:# +2+ 5#6# #8+2# ++&6$'& ' 5#6*#01#

5+$+6'3 + # +#& + 5'&#+$+, '$#5'$$' + 3'2#$+ # &/# $#$, #&%$4&# +

*3'$' 5/32'' +6 F#&'3+=', '36 + 5#6*'&'& # &+/3'# +$5#$&'# 5#6 #/&#&/# &#*5' 5#$/6# $# 9&'3. O $#$ # /86+# ' 2+&' '$43+, +$# 5#6#

&+/3'#; /6'+ ("?,), 5$=' (>), *&#+$' (,%@>!!%), '05'&+ &+/#&+

(, in natura + ,> $# 3#3='#), '05'&+ #32+ #' (?,> in natura +

",? $# 3#3='#), 3*# (>,Q%@>!!%), 2'6$' C (>","6%@>!!%), 5'&#+$+

(,QW%@>!!%), '$#5'$$' (!,"6%@>!!%) + 3'2#$+ (>,Q6%@>!!%). O &+/3'#

6#&'&'6 7/+ +2# '# +'7/+ # $#$ +6 &+3'01# '# &/# 5#6*'&'# 7/'$#

2'6$' C, 5'&#+$+, '$#5'$$' + 3'2#$+, +3+ *#/ '2'+ '$#'$+,

/5'$# '6 # +/ *#+& +&'*K/5#. T'686 + +'5#/ +6 &+3'01# '# 3*# +

*&#+$', # 7/+ # #&$' $/&5#$'36+$+ 6*#&'$+. P#&6, 7/'$# '# '05'&+, /6'+

+ 5$=' +6+3:'$+ 6'#&' # &/#. A$' '6, 6' +/# &+3'5#$'# /'

5#6*#01#, '36 # +/# #8&+ #5'+, 1# $+5+4&# *'&' 5#6*&#2'& +/

++# +&'*K/5#.

P'3'2&'-5:'2+; Morinda citrifolia L.J $#$J 5#6*#01# 5+$+6'3.



LISTA DE FIGURAS E TABELAS

F%/&' >; Á&2#&+ + $#$ ...................................................................................... >

F%/&' ; F#3:' + 3#&+ + $#$ ......................................................................... >

F%/&' + ; F&/# 6'/&# + $#$ ..................................................................... >

F%/&' ; S+6+$+ + $#$ .................................................................................. >

F%/&' ; G&45# ' 5/&2' *'&1# + %35#+ ..................................................... !

F%/&' Q; G&45# ' 5/&2' *'&1# .......................................................................

T'8+3' >; X/'$5'01# + '05'&+ &+/#&+ (AR) +6 '6#&' 3' +6 ! $6 + '8#&8$5' !

T'8+3' ; X/'$5'01# # +#& + '05'&+ #' ............................................

T'8+3' ; C#6*#01# 5+$+6'3 # &/# + $#$ ............................................ "

T'8+3' ; T+#&+ + 5'&#+$+, '$#5'$$' + 3'2#$+ # &/# $#$...... "

SUMÁRIO

LISTA DE FIGURAS E TA9ELAS .............................................................

> INTRODUÇÃO ........................................................................................... ?

O9ETIVOS ............................................................................................... >



.> G+&'3 ........................................................................................................... >. E*+55# ................................................................................................. >

REVISÃO DE LITERATURA ...................................................................... >

.> D+5&01# # $#$ ....................................................................................... >. P&$5*' 5#6*#$+$+ # $#$ ................................................................ >. B+&#$$' ..................................................................................................... >. A2'+ 8#3%5' # $#$ ..................................................................... >"..> E+# '$65&#8'$# .................................................................................. >".. A2'+ '$5'$5+&%+$' .......................................................................... >?.. A2'+ '$#'$+ ................................................................................ !.. A2'+ '$$3'6'&' ........................................................................... .. A2'+ '$'3%5', '$#35' + +'2' ............................................. .. A2'+ 5'&#2'5/3'& ............................................................................ . E/# #8&+ #5'+ ...........................................................................

. D+$0+ + /$0+ # 5#6*#$+$+ '$'3'# ................................. ?

METODOLOGIA ........................................................................................ .> D+3$+'6+$# ' *+7/' ......................................................................... . C'&'5+&='01# ' '6#&' ........................................................................ . E*+&6+$# &+'3='# ............................................................................ ..> D++&6$'01# + /6'+ ......................................................................... .. D++&6$'01# + 5$=' ............................................................................. .. D++&6$'01# + *&#+$' ........................................................................ Q.. D++&6$'01# + 5'&8#&'# ......................................................... ?.. D++&6$'01# + 3*+# (+&'# +&+#) ................................................. .. D++&6$'01# + 2'6$' C ...................................................................... ..Q D++&6$'01# + 5'&#+$+ .................................................................. .." D++&6$'01# + '$#5'$$' + 3'2#$+ ............................................. Q

RESULTADOS E DISCUSSÃO ................................................................. "

CONCLUS[ES ..........................................................................................

REFER\NCIAS 9I9LIOGRÁFICAS ..........................................................



1 INTRODUÇÃO

A Morinda citrifolia L. (2/3%'&6+$+ 5#$:+5' 5#6# $#$) /6' *3'$'

$'2' # /#++ ' Á' (I$#$') + A/&43' + +6 /6' &8/01#*'$&#*5'3. F'= *'&+ ' '63' Rubiaceae, /8'63' Rubioidae + '686

5#$:+5# 5#6# canary wood (A/&43'), Indian mulberry (I$%3'+&&'), Kura (F),

mora de la Índia (E*'$:'), $#$ (H'2'), +$&+ #/&#. ] #3+&'$+ ' 5#$0+

'68+$' +&+6'6+$+ +'2#&42+, *# 5'*'= + 5&+5+& +6 #3# $&+,

45#, '35'3$# + *#+ +'& *&++$+ '$# +6 4&+' 6/# +5' 7/'$# 6/#

6' (NELSON, !!). A :'+, ' &'=, ' #3:' + # &/# +' *3'$' K6 #

/3='# *+3# *#2# ' 3:' # P'55# 5#6# 6+5'6+$# *'&' &''& +63'&%' +5'3' 2+&' #+$0'. A &'= + # &/# 1# /3='# *&$5*'36+$+ *'&'

'36+$'01# + 6+5'6+$# (LIU et al ., !!>J NELSON, !!).

E6 +&+$+ *'&+ # 6/$#, ++6 '# #8&+ # /# + *3'$'

5#6 $ 6+5$'. S'8+-+ 7/+ ' +*5+ #&/$' ' P#3$' +1# +$&+ '

6' /3=''. D+$&+ ' *3'$' 6+5$' +5#8+&' *+3# '$5+&' #

*#3$#, # $#$ /6' ' &'5#$', 7/+ +6 # /'' :4 6' + !!! '$#$' P#3$' + +4 +$&+ ' 5$5# +*5+ 6+5$' 6' /'' $' 6+5$'



'3+&$'2', /$'6+$+ 5#6 Aloe vera L., Allium sativum L, Panax ginseng C.A.

M'^+& + Cymboogon citratus (DC) S'* . N# 36# '$#, # $#$ +6 #

'*#$'# *#& +& %&'$+ 2'3#& +&'*K/5# + $/&5#$'3 (_ANG et al ., !!J RIVAS et

al., !!).

] '8# 7/+ ' 7/'3'+ ' *3'$' + # 5#6*#$+$+ $/&5#$'

5#$# $+' +1# &+'6+$+ '#5'# '# #3# '# 7/'3 +3' 5&+5+6.

X/'37/+& '#&, 5#6# # +&&+$#, # 536', ' 3#5'3='01# %+#%&45', +$&+ #/&#, 7/+

++&5+ $3/K$5' $' 5#$0+ # #3#, *#+ '+'& # 5#$+# ' *3'$' (LIU et

al., !!Q). A 5#6*#01# 7/65' # $#$ +&+ 8''$+ +6 5'' *'&+ ' *3'$'.

E68#&' ' 5#6*#01# # &/# 5&/ +$:' # 5'&'5+&='', ' 5#6*#01# 7/65'5#6*3+' # &/# '$' $1# # &+3''', *#& # ' $#&6'0+ ' &+*+# # &/#

+ $#$ '$' 1# 36'' (YANG et al ., !!Q).

R+5+$+6+$+, # /5# + $#$ +6 # 5#6+&5'36+$+ *&#5+'# +

&8/# $+&$'5#$'36+$+ 5#6# /*3+6+$# +5#. R+3'2'6+$+

+5#$:+5# :4 *#/5# '$#, ++ *&#/# '/'36+$+ 6#26+$' /6' $&'

83#$4&'. A36 # /5#, # * +$5'*/3'# #&$#/-+ *#*/3'& $' Á', A6&5' #

N#&+ + E/&#*' (NANDHASRI et al ., !!J YANG et al ., !!Q).

E/# &+5+$+ #8&+ ' *&#3+&'01# + *&#/# 5#6+&5' 6#&'&'6

7/+ # '8&5'$+ + *&#/# 8'+ + $#$ +1# '*#$'$# /6' &+ +

'&8/0+ +&'*K/5' ' ++. E' '&8/0+ 1# 8'+'' $# /#

&'5#$' # $#$ $' P#3$' + +6 &'%6+$# + +/# 5+$5# &+5+$+,

$53/$# ' '2'+ ++ $# &''6+$# + 5$5+& (MCCLATCHEY, !!). O /5#

' &/' *#/ '3' +6'$' $' 6+5$' '3+&$'2' *'&' +&+$+ *# +#+$0', ' 5#6#; '&&+, '8++, :*+&+$1# + #/&' #+$0'

5'&#2'5/3'&+, #&+ 6/5/3'&+, *&#83+6' 6+$&/', #&+ + 5'8+0', AIDS,

5$5+&+, 35+&' %4&5', +$#&+, +*&+1#, +$3'+, *&#83+6' %+2#,

#2+&#+ + &''6+$# + %&*+ + &+&'# (_ANG et al ., !!).

M/# 5#6*#$+$+ K6 # +$5'# $# $#$, 5#6#; +5#*#3+$',

45# #5'$5#, *#4#, 2'6$' C, +&*+$+, '35'3+, '$&'7/$#$'

(&/8'$' + '$&'7/$#$' %35#+#), 5'&#+$#, 2'6$' A, 45# 3$#35#, '3='&$',



'6$#45#, 45# 5'*&5# +, *&$5*'36+$+, ' *&#+&#$$', /6 *&+5/&#& $'/&'3

' +&#$$', ' 7/'3 '&8/' # ++# 6+5'6+$## # $#$ (_ANG et al ., !!).

N# 9&'3, # /*+$', +6 ## # 2+5/3# + 5#6/$5'01#, 7/'37/+&

*&#*'%'$' # /5# !a"itian #oni$ , '8&5'# *#& /6' +6*&+' $#&+-'6+&5'$',

7/+ '&8/' *&#*&+'+ +&'*K/5' ' ++ *&#/#. A ++&6$'01# ' A%K$5'

N'5#$'3 + V%3$5' S'$4&' (ANVISA) # */835'' +6 ! + '8&3 + !!, $#

D4&# O5'3 ' U$1# *#& 6+# ' R+#3/01# – RE $` Q + ' R+#3/01# – RE $` ?.

O *&#/# *#/ &+%&# $# M$&# ' A%&5/3/&', +$# 6*#&'#, &8/# +

5#6+&5'3='# $# 9&'3 *#& 2+&' +6*&+'. E' +6*&+' '3+%'6 '

*&#*&+'+ 6+5'6+$#' # $#$ 5'' +, *#& 3+, $# 9&'3, # 6+5'6+$#1# # $5# 7/+ *#/+6 + *#+6 '3+%'& *&#*&+'+ 6+5$' #/ 5/&'2' +

*#+6 +& 5#6+&5'3='# +*# + &+%&'# $' ANVISA, 7/+ '+%/&' /'

+545' + +%/&'$0' (ANVISA, !!).

D+2# /3='01# + $#$ $# 9&'3 + $# 6/$# 5#6 $'3'+

+&'*K/5' + $/&5#$', # *&++$+ &'8'3:# +6 5#6# #8+2# ++&6$'& '

5#6*#01# 5+$+6'3 + +#&+ + 5'&#+$+, '$#5'$$' + 3'2#$+ ++

&/#, #&%$4&# + *3'$' 5/32'' +6 F#&'3+=', C+'&4, '36 + 5#6*'&'& #&+/3'# +$5#$&'# 5#6 #/&# &/# &#*5' 5#$/6# $# 9&'3.



2 OBJETIVOS

2.1 Geral

• D++&6$'& ' 5#6*#01# 5+$+6'3 + # +#&+ + 5'&#+$+,

'$#5'$$' + 3'2#$+ # &/# $#$ (Morinda citrifolia L.), #&%$4&# +

*3'$' 5/32'' +6 F#&'3+=', C+'&4, 8+6 5#6# 5#6*'&'& # &+/3'#

#8# '# + #/&# &/# &#*5' 5#$/6# $# 9&'3.

2.2 Ese!"#$!%s

• D++&6$'& ' 5#6*#01# 5+$+6'3 (5'&8#&'# #', '05'&+ &+/#&+

+ '05'&+ #32+ #', *&#+$', 3*#, /6'+, 5$=', 2'6$' C),

# &/# $#$, #&%$4&# + *3'$' 5/32'' +6 F#&'3+=', C+'&4.

• D++&6$'& # +#&+ + 5'&#+$+, '$#5'$$' + 3'2#$+ # &/#

$#$ #&%$4&# + *3'$' 5/32'' +6 F#&'3+=', C+'&4.



• C#6*'&'& # &+/3'# #8# 5#6 #/&# &/# &#*5' 5#$/6# $#

9&'3.

& REVISÃO DE LITERATURA

&.1 Des!r$'(% )% *%*$

D+ '5#&# 5#6 Ma33+& (!!Q), ' 53'5'01# 8#$5' # $#$ '

+%/$+;

• R+$#; P3'$'+.

• D21#; M'%$#3#*:^'.

• C3'+; M'%$#3#*'.

• O&+6; G+$'$'3+.

• F'63'; R/8'5+'+.

• GK$+&#; M#&$'.

• E*5+; Morinda citrifolia.

• N#6+ 5+$5#; Morinda citrifolia L.

A 4&2#&+ (F%/&' >) *#+ 5:+%'& ' '*&#6''6+$+ &K 6+&# + '3/&'$' 6'/&'+. A 3#&+ (F%/&' ) *#/+6 #&6'# #2'3, 5#6 *+$5/3# 3#$%# +



5#&#3' 8&'$5'. A #3:' (F%/&' ) 1# '8/$'$+, +3*5', 3'&%' + 8&3:#'

(NELSON, !!J CHAN-9LANCO et al ., !!).

F%/&' >; Á&2#&+ + $#$. F%/&' ; F#3:' + 3#&+ + $#$.F#$+; N+3#$, !!. F#$+; N+3#$, !!J '&7/2# *+#' (!!Q).

O &/# (F%/&' + ) 8&'$5# '6'&+3'# 7/'$# 6'/&#, '36 +

6'5# + # + +'3' /6 '&#6' &'$0## + #&+ + 45# 5'*&5#. A *#3*'

/5/3+$' + %+3'$#' (NELSON, !!J CHAN-9LANCO et al ., !!).

F%/&' + ; F&/# 6'/&# + $#$. F#$+; '&7/2# *+#', !!Q.

A +6+$+ (F%/&' ) K6 /6' 56'&' + '& $' + *#+6

*+&6'$+5+& 242+ 6+6# '* 3//'&+6 $' 4%/' *#& 6++ (NELSON, !!).



F%/&' ; S+6+$+ + $#$. F#$+; N+3#$, !!.

&.2 +r$*!$a$s !%,%*e*-es )% *%*$

A*&#6''6+$+ >! 5#6*## #7/65# K6 # +$5'# $#

$#$, +$# 7/+ ' 6'#&' ++ 1# 5#6*## +$35#, 45# #&%$5# +

'35'3+. D# 5#6*## +$35#, # 6' 6*#&'$+ 1# ' '$&'7/$#$' (+;

'6$'5'$'3), '36 + '/5/8$', '3='&$' + +5#*#3+$'. O *&$5*' 45#

#&%$5# 1# # 5'*&35# + # 5'*&5# + # *&$5*'3 '35'3+ ' +&#$$'. O

+&*+$# '686 1# 8''$+ 5'# $' 3+&'/&', '36 # &+ (CHAN-

9LANCO et al ., !!J LAVAUT + LAVAUT, !!J bAMIYA et al ., !!). A +5#*#3+$', *+&+$5+$+ '# %&/*# ' 5/6'&$', +8+ '2'+

#7/65' 63*3'. E6 24&# +/# 5+$5#, ' +5#*#3+$' +6 #

'*#$'' 5#6# ++&5+$# '2'+ :+*'#-*&#+#&', '36 + +& $8#&' #

5&+56+$# + %sc"eric"ia coli + + *#/& '2'+ '$8'5+&'$' 5#$&'

&ta"ylococus aureus, &tretococcus neumoniae, &. s., Klebsiella neumoniae,

Proteus mirabilis, Pseudomonas aeruginosa + 'aemo"ilus influen(a. E'

8'5&' 1# &+*#$42+ *#& +#&+$ 5#6# $#5'01# '36+$'&, +*5+6',

*$+/6#$', $+&+, $+50+ /&#%+$', +$#5'&+, $+50+ &+*&'&',

%'&#+$+&+, +$&+ #/&'. E+ 5#6*## '686 +6 # '*#$'# 5#6# /6

*#+$+ '$$3'6'&#, '36 + 3 +6 '*35'0+ *5', ' 5#6# '$*&5#,

'$'3%5#, '$*5# + :*#+$2# (YANG et al., !!Q).

O '6$'5'$'3 /6' '$&'7/$#$', &+5+$+6+$+ 5'&'5+&='', + 7/+

+6 6*#&'$+ *&#*&+'+ /$5#$', *&$5*'36+$+ ' '$5'$5+&%+$'. E3+

'686 + '#5' '# $5&+6+$# ' '2'+ +6/3'$+ #8&+ # +6' 6/$+.

E+ +6' *&+/5'# + '#5' '# 5$5+&, '&&+ &+/6'+ + AIDS. O



'6$'5'$'3 '2' ' 53/3' T 7/+ +&#+6 ' 53/3' /6#&' (CHAN-9LANCO

et al ., !!J LAVAUT + LAVAUT, !!).

O 45# 5'*&5# + 5'*&35# 1# # &+*#$42+ *+3# ##& #&+ #

&/# 6'/&# + $#$. O &+&*+$+ 1# +&*+$+ 5#$+$# /6 +7/+3+#

5'&8$5# C!, 7/+ #&6'6 /6 %&'$+ %&/*# + /8$5' $'/&', $53/$# #

++&+ +, 5#$+7a+$+6+$+, # ++&. O &+ K6 # &+3'5#$'# '#

++# '$#'$+ in vitro (NELSON + ELEVITCH, !!J RODRIGUEZ + PINEDO,

!!).

&.& er%*$*a

C+$' &+3''6 ' +K$5' + /6 *&+5/&#& $'/&'3 + +&#$$', /6

'35'3+, 5:'6'# + *&#+&#$$', $# &/# + $#$. A *&#+&#$$' 5#$2+&' +6

+&#$$' $# #&%'$6# *+3' +$=6' *&#+&#$$'+. A +&#$$', +%/$#

*+7/'#&+, + 5#68$' 5#6 ' *&#+$' :/6'$', 6+3:#&'$# /'

/$5#$'3'+. A +' +&#$$', *#&'$#, '&8/' ' 6'#&' # ++# 8+$5#

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CHAN-9LANCO et al ., !!J YANG et al ., !!Q).

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+'2', 5'&#2'5/3'&+ + :*#+$2' (_ANG et al ., !!J CHAN-9LANCO et

al ., !!J DENG et al ., !!Q). V+'6# ' +%/& '3%/6' +' '2'+ + ++#

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aureus, )acillus subtilis, %sc"eric"ia coli, &almonella e &"igela. E+ +3+6+$#

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yrogene. T'686 # +6#$&'# 7/+ # +&'# + $#$, #8# '&'2 +

+'$#3 + :+'$#, *#/+6 /6 ++# '$/8+&5/3##, *# $8+6 '*&#6''6+$+

" ' ? # 5&+56+$# + Mycobacterium tuberculosis (CHAN-9LANCO et al .,

!!).

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(ELDRIDGE, !!).

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6+4'+ (ELDRIDGE, !!).

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5#5# (*&#+%+6 5#$&' $+#*3'' '#5'' ' 2&/), 53/3' +&/#&'

(Killer ) $'/&' (1# 3$5# 5'*'=+ + +&/& 53/3' /6#&' +6 7/'37/+& +$83='01# *&2'), 6'5&'%# (*#+6 6''& /6#&+ '&'2 + 6+5'$6#

+6+3:'$+ 7/+3+ /3='# *'&' 6''& 65&8# #/ '&'2 ' +5&+01# #

'#& + $+5&#+ /6#&'3 c – TNF-c) + 6+5'$6# :/6#&' (*#+6 *'&5*'& '

+&/01# + 53/3' /6#&' '&'2 ' '2'01# # 5#6*3+6+$# + $/01# '

5##5'+ 5+3/3'& '$5#&*#-+*+$+$+ *+3' 53/3' *iller $'/&') (COTRAN

et al ., !!!).

A *'&& # &'5#$'6+$# + /6' *'&5/3' + 53#&#6+'$# #32+3 +

/6 +&'# + &/# + $#$, # #3'# /6 $/#& + 7/$#$' &+/'+ (XR)

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+'# &+/=# # '$#'$+, 5#6# # c-#5#+&#3 + ' 5#+$=6' X>!. O

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'2'+ 5#$+&'' *&#+#&' $# +'# + $5# ' 5'&5$#%K$++ (PA_LUS et

al ., !!).

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(CHAN-9LANCO et al ., !!).

O/&# %&/*# '*#$K +/#/ 6' +*+55'6+$+ ' $3/K$5' #

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+ 1# '3'6+$+ 6'3%$' (CHAN-9LANCO et al ., !!).

&./.& A-$0$)a)e a*-$%4$)a*-e

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5#$/6# + &/' + 2+%+' *&#+%+6 # +&+ :/6'$# 5#$&' # ++#

#'2#, $8$# ' +*5+ &+'2' + #%K$# (ZIN et al ., !!J LIU et al .,!!Q).

E6 #/&# +/#, ' *'&+ #32+3 # +&'# + 6+'$#3 (M+OH) + &/#

+ $#$ +2+ 6#+&'' '2'+ '$#'$+. E' *'&+ # */&5'' *#&

5&#6'#%&'' &+*+', 7/+ 3+2#/ '# #3'6+$# + # $#2# &+ %35#+#;

# c-:&#'##+# (C>QHO>>) + # e,Qe-+*#-"-+*-+*3+$#+# (C>QHO>),

'36 + #/&# +=+++ 5#6*#$+$+ 5#$:+5#. T## # 5#6*## #3'#

#8# $++ +/# #&'6 '2'3'# 7/'$# 4 /' '2'+ '$#'$+, +$# '



$+#%35'$', A6+&5'$$' A, +6#$&'# %$5'$+ '2'+ '$#'$+ (SU et

al ., !!).

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(EOA5) + >-8/'$#3 (9/OH) + /5# # &/# + $#$ +&6+$'#, #&%$4&# '

C:$', 5#$53/&'6 7/+ ++ /5# '*&++$' 5#$+&42+3 '2'+ '$#'$+, 6'

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+ $#$ +6 +&+$+ +'# + 6'/&'01# + 7/+ *''&'6 *#& *&#5+# +

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&././ A-$0$)a)e a*-$$*#la,a-r$a



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8&#+ + $+5&#+ +5/'3 (COLLINS, !!!).

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+5/&+56+$# $1# +$=645# (9O99IO + 9O99IO, !!>).



/ METODOLOGIA

/.1 Del$*ea,e*-% )a es;9$sa

A *+7/' &+'3='' # # *# 7/'$'2', +5&2', + 5'&4+&

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et al. (!!).

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5/&2' *'&1# + %35#+. P'&' ' #8+$01# ' 5/&2' *'&1# + '05'&+ &+/#&+

(AR) # *&+*'&'' /6' #3/01# + %35#+ >! 6M ' +%/$+ 6'$+&'; !,! % +

%35#+ #32' +6 4%/' *'&' ! 6L + #3/01#. A 5/&2' *'&1# + %35#+,

#8' ' *'&& + 5#$5+$&'0+ +&+$+ +', '* 3+/&' # 9&'$5#,

6#&'' $' '8+3' >> + $' %/&' .

A 3+/&' ' #3/01# 5#$+$# ' '6#&' + ' # 5#$&#3+ (9&'$5#) #

&+'3='' +6 /6 +*+5&#6+&# U3&#*+5 >!! +6 /6 5#6*&6+$# + #$' +

! $6. P'&' ' 3+/&' # /8# 5#$&#3+ (9&'$5#) # '5#$'# > 6L + DNS +6 >,

6L + 4%/' +3'' +6 /8# + +$'#, 7/+ #&'6 3+2'# '# 8'$:#-6'&' + +6

+%/', #&'6 '5#$'# 6' Q, 6L + 4%/' +3''.

T'8+3' >; X/'$5'01# + '05'&+ &+/#&+ (AR) +6 '6#&' 3' +6 ! $6

+ '8#&8$5'.

T/8# G35#+

(>!6M)

Á%/' A.R. A.R. R+'%+$+p A8. ! $6

N° (6L) D+3'' (µM#3+) (/%) DNS (6L) L+/&'>-9 !,! >, !,! !,!! >,! !,!!!

!, >, ,! !, >,! !,>">

!, >,> ,! Q!, >,! !,Q!

!, !,? ,! >!"!,? >,! !,?Q

F#$+; M33+& (>??)



F%/&' ; G&45# ' 5/&2' *'&1# + %35#+.

A* # *&+*'&# # &+'%+$+, # *+'# >% + *#3*' + $#$ +@#/ +*#3*' 3#3='' ('6#&') + +' #&'6 #32' +6 ! 6L + 4%/' +3''

*'&' +*# +&+6 /86+' ' /6' 3+2+ '%'01# ' ' 5#6*3+'

:#6#%+$+='01#. E6 +%/', # :#6#%+$+='# # 3&'# +, ++, #&'6

&'$+&# >, 6L *'&' /8# + +$'#, #$+ # '5#$'# >6L + DNS. A*

++ *&#5+#, # /8# #&'6 '%'# + 5#3#5'# +6 8'$:#-6'&' *#& 5$5#

6$/# +6 4%/' +&2+$+. A +%/& # 6'+&'3 # /86+# ' /6 8'$:# + %+3# +

#&'6 '5#$'# Q, 6L + 4%/' +3'' +6 5'' /8# *'&' 5#6*3+'& >! 6L.

F$'36+$+ # &+'3='' /6' 3+/&' ' ! $6 +6 /6 +*+5&#6+&# U3&#*+5

>!!.

P'&' # 5435/3# *&45# + '05'&+ &+/#&+, # /3='' ' +7/'01# '

5/&2' + %35#+, 6#&'' $# %&45#, ' '8#&8$5', # *+# ' '6#&' + # '#& +

3/01#. O &+/3'# # '# +6 *#&5+$'%+6.

A05'&+ #32+ #';

N# 6## *'&' ++&6$'01# + '05'&+ #32+ #', # 6'+&' +

&+'%+$+ /3='# #&'6; '$&#$' (?,>!-:&#-?-##'$:&'5+$')J 45# /3&5#

P.A, 87/+&J 8'1# + 2&#J /$3 + 3&'01#J **+' 2#3/6&5'J /8# + +$'#J

8'$:#-6'&' *'&' 4%/' +&2+$+J +*+5&##6+&#J 8'3'$0' '$'35'.

A 7/'$5'01# + '05'&+ #32+ #' # +6'' +6 &+3'01# ' /6'

5/&2' *'&1# + %35#+. P'&' ' #8+$01# ' 5/&2' *'&1# + '05'&+ #32+



#' # *&+*'&'' /6' #3/01# + %35#+ + '$&#$' ' +%/$+ 6'$+&'; #&'6

#32# >! 6% + %35#+ */&' +6 4%/' +3'' $/6 8'31# 2#3/6&5# + >!!

6L. E6 #/&# 8'31# 2#3/6&5# + >!! 6L, # *&+*'&'' /6' #3/01# #8' '

*'&& + !! 6% + '$&#$' #32# +6 HSO 5#$5+$&'# ('$&#$' > em

H2SO4 28 N). A *'&& ' 3+/&' # 9&'$5# ' ! $6 +6 +*+5&##6+&# U3&#*+5

>!!, #8+2+-+ ' 5/&2' *'&1#.

A ++&6$'01# ' 5/&2' *'&1# + %35#+ 6#&'' $' '8+3' + $'

%/&' Q.

T'8+3' ; X/'$5'01# # +#& + '05'&+ #'.

TU9OS S. PADRÃO VOLUME (6L)

%35#+

ÁGUA (6L) ANTRONA∗ (6L) A9S. ! $6

9&'$5# - - >,!! !,!!!P> ! µ% !,! !,? !,!!"+2 1= 3 =71= =7>= 2 !,>!"P > µ% !,> !," !,>+/ 2= 3 =72= =7?= 2 !,>!P µ% !, !,Q !,+8 &= 3 =7&= =7@= 2 !,"PQ µ% !, !, !,>+? /= 3 =7/= =78= 2 !,

A6#&' - >,!!

F#$+; Y+6$ + _33 (>?).



F%/&' Q; G&45# ' 5/&2' *'&1#

A* *&+*'&# ' #3/0+, # *+'# >% ' '6#&' 7/+ # #32'+6 >!! 6L + +'$#3 "!. A 6/&' # 3&'' +, +', # &+&'' /6' '37/#' +

>! 6L *'&' >!! 6L + 4%/' +3'' (>;>!). F#&'6 5#3#5'' '37/#' 2'&''

' '6#&' +6 /8# + +$'# + 6+&# +6 &+5*+$+ 5#6 %+3#. E6 +%/'

5'' '37/#' ' '6#&' +2+ +/ 2#3/6+ 5#6*3+'# *'&' > 6L, 5#$#&6+ 6#&'

' (T'8+3' ). A* ++ *&#5+6+$#, # '5#$'# +6 5'' /8# 6L # &+'%+$+

+ '$&#$' ('$&#$' > +6 HSO " N) + # /8# #&'6 '%'# + &+#&$'2'6

6+''6+$+ '# 8'$:# + %+3#. E6 +%/', # /8# #&'6 3+2'# *'&' 8'$:#-

6'&' +&2+$+ *#& " 6$/# + +*# #&'6 +&'# +6 4%/' %+3'' *'&' ' 3+/&'

' '8#&8$5' +6 +*+5&##6+&# U3&#*+5 >!! ' ! $6. U3=#/-+ 5#6#

*'&1# ' %35#+ + ' '8#&8$5' #&'6 3' ' ! $6 . O '05'&+ $1#-

&+/#&+ #&'6 '2'3'# *#& +&+$0' +$&+ # '05'&+ #32+ #' + #

'05'&+ &+/#&+.

P'&' # 5435/3# *&45# + '05'&+ #32+ #', #&'6 /3='# '

+7/'01# ' 5/&2' + %35#+, 6#&'' $# %&45#, ' '8#&8$5', # *+# '

'6#&' + # '#& + 3/01#. O &+/3'# # '# +6 *#&5+$'%+6.

/.&.5 De-er,$*a'(% )e l$")e%s e4-ra-% e-6re%

O 6## /3='# *'&' ' ++&6$'01# + %#&/&' # # + S#:3+,

+5&# *#& I$/# A#3# L/= (!!) (6## !@IV), &+'3='# 5#6 '6#&' #

&/# 3#3='#.



O 6'+&'3 /3='# #; 5'&/5:#, '3%#1#, 5#$+$'#&, +&'#& +

S#:3+, 8'31# 5#3+#&, 8'3'$0' '$'35', 5'*+3' + 3/# 3'6$'&, &#'-+2'*#&'#&,

8'31# 2#3/6&5#, #32+$+ :+'$#.

O 8'31# 5#3+#& + # 5'&/5:# 5#6 '3%#1# #&'6 *+'# +6 8'3'$0'

'$'35'. E6 +%/', #&'6 *+'# ,!Q % + *#3*' + $#$ 3#3='' $# 5'&/5:#

+ +6, +%/' #&'6 5#8+&# 5#6 '3%#1#. A* # 8'31# +& ''*'# '# /8#

+&'#& # 5#3#5'# $++ # 5'&/5:# 5#$+$# ' '6#&' *+''. D+*# +'

+'*', # 5#3#5'# # :+'$# $# 8'31# '&'2 # /8# +&'#& ''*'# '# 6+6#

(/6' 2+= + 6+' ' '3/&' # &'6# 6+$#& # +&'#&, #/ +', ' 5'' 2+= 7/+ '$%/

' '3/&' # &'6# # /8#, # &+'%+$+ *'#/ *'&' # 8'31#. E' +'*' # +' +65'*+3').

O 5#$/$#, 8'31# + /8# +&'#&, # ''*'# '# 5#$+$'#&, $#

'*'&+3:# + S#:3+. A* #, ' #&$+&' 5#6 4%/' + &/' # '8+&' *'&', '&'2

+ /8# + 34+, +$&'& + '& 4%/' $# 5#$+$'#&. D+*#, # '*'&+3:# # 3%'# +,

7/'$# # :+'$# '$%/ # *#$# + +8/301#, +/ 2'*#&+ *''&'6 *+3#

5#$+$'#& '&'2 # 8&'0# 6'#& # /8# ' '35'$0'& # 5#$+$'#&. O :+'$#5#$+$#/-+ + 5'/ +6 #&6' + %#' #8&+ ' '6#&' $# 5'&/5:# ' '$%& '

'3/&' # &'6# 6+$#& + 2#3#/ *'&' # 8'31#. A %#&/&' 5#/ $# 8'31#. E+ *&#5+#

+ &+*+/ *#& > :#&'. T+&6$'# ++ *&#5+#, # '*'&+3:# # +3%'# *'&' '

&+&'' # 5#$/$# (8'31# + /8#) # 5#$+$'#&.

D+*#, ' '6#&' + #32+$+ + %#&/&' # &'$+&' *'&' /6 8'31#

2#3/6&5# *&+2'6+$+ *+'# + '* ' &'$+&K$5' # &+'3='' /6' $#2'*+'%+6 + # 8'31# 5#6 ' '6#&' # +$5''# $# &#'-+2'*#&'#&, 7/+ # 3%'# '

/6' 2+3#5'+ + ' +6*+&'/&' + Q #C, ' 5#6*3+' +2'*#&'01# # :+'$#.

E6 +%/', # 8'31# 5#6 ' '6#&' #&'6 *+'# *'&' #8+$01# ' 6'' +

%#&/&'.

O 5435/3# *'&' #8+$01# ' 7/'$'+ + 3*# # +# ' *'&& + /6'

&+%&' + &K, /3='$#-+ ' 6'' + %#&/&' #8' + # &+/3'# # '# +6

*#&5+$'%+6.



/.&.8 De-er,$*a'(% )e 0$-a,$*a C

P'&' '$43+ ' 2'6$' C, #&'6 /3='' '6#&' # &/# in natura.

A '$43+ # +' +6 &*35''. O 6## /3='# # +5&# *#& S&#:+5f+& +

H+$$$% (>?Q).

O 6'+&'3 + # &+'%+$+ /3='# #&'6; %&'3 + '36#'&=J 8+5f+& >!!

6LJ 8'31# 2#3/6&5#J +&3+$6+^+& > 6LJ 8/&+'J 2&# 68'& (#3/01# + T336'$),

, 53#&#-+$#3 $#+$#3 (DFI), 45# #435#, 85'&8#$'# + # + 45#

'5&85# (## P. A.).

P'&' # *&+*'&# ' #3/01# + T336'$ (DFI - , 53#&#-+$#3 $#+$#3)

!,! #&'6 &/&'# ! 6% + DFI +6 %&'3, 5#6 *+7/+$' *#&0+ + 4%/'

+3'' '7/+5' (!°C) + +' 6/&' # 3&'' *'&' # 8'31# 2#3/6&5# + !

6L. X/'$# /# +'2' &/&'# + 3&'# (*'*+3 + 3&# +6 5#3#&'01# '=/3),

#&'6 '5#$'# > 6% + N'HCO (85'&8#$'# + # '$&#) 36'

*#&0+ + 4%/' +, +6 +%/', +' #3/01# # 3&'' + 6'$' +6 +6*+&'/&'

'68+$+ ' 5#6*3+# &+&'6+$# *'&' +*# 5#6*3+'& # 2#3/6+ # 8'31# 5#64%/' +3''. A #3/01# # %/'&'' +6 &'5# +5/&#, +6 %+3'+&'.

P'&' # *&+*'&# + !! 6L ' #3/01# + 45# #435# !, #&'6

#32# ,% + 45# #435# +6 '*&#6''6+$+ ! 6L + 4%/' +3''. A

#3/01# # &'$+&' *'&' 8'31# 2#3/6&5#, 5/# 2#3/6+ # 5#6*3+# 5#6 4%/'

+3'' *'&' *#+&#&6+$+ '&6'=+$'& +6 %+3'+&'.

P'&' *&+*'&# ' #3/01# *'&1# + AA µ%@6L #&'6 #32# 6% +

AA (45# '5&85#), + 8#' 7/'3'+, +6 >!! 6L + 45# #435# !, (%+3'#) #

5#$+# # &'$+&# *'&' 8'31# 2#3/6&5# + >!! 6L, + # 2#3/6+ #

5#6*3+'# 5#6 45# #435# !,.

A* ' +&'01# + :#6#%+$+='01# ' '6#&' $# 37/5'#&, *'&'

*&+*'&# # +&'#, #&'6 *+'' '*&#6''6+$+ > % + 5'' '6#&' (&K),7/+ +2+&'6 *&#+%' ' 3/= + #%+$'01#, + #&'6 '5#$'# ! 6L + 45#



#435# !, (&+&%+&'#). O 2#3/6+ # 5#6*3+'# 5#6 45# #435# !, +6

8'31# 2#3/6&5# + >!! 6L.

P'&' *'&#$='01# ' #3/01# + T336'$ !,! 5#6 AA, #&'6

6/&'# 6L ' #3/01# + AA ( µ%@6L) +6 E&3+$6+^+& + > 6L, 5#6 4%/'

+3'' ' 5#6*3+'& # 2#3/6+ + ! 6L. E6 +%/', # &+'3='' ' /3'01#

5#6 ' #3/01# + T336'$ &+&%+&'', ' # *#$# + 2&'%+6, &+# 53'&#,

*+&+$+ *#& > +%/$#. O &+'%+$+ # &+/=# + '=/3 ' $5#3#& + +6 6+#

45#, #&$#/-+ &+#. F#&'6 +' &K &+*+0+ ++ *&#5+# *'&' # 5435/3#

# /3# # &+'%+$+, #/ +', ' 7/'$'+ + AA *'&' /3'& > 6L ' #3/01# +

T336'$.

C435/3# # /3#; G'#/-+ +6 6' , 6L ' #3/01# + T336'$ *'&'

/3'& 6L + AA ( µ% m ! µ%).

, 6L - ! µ%

>,! - B m Q," µ%@6L m /3#.

P'&' ++&6$'01# + AA $# +&'#, #&'6 6/&'# 6L ++, +6

+&3+$6+^+& + > 6L, 5#6 4%/' +3'' ' 5#6*3+'& ! 6L + ' #3/01# +

T336'$ &+&%+&'' # /3'' ' # *#$# + 2&'%+6, 5#6# $5'# '$+&#&6+$+.

F#&'6 +' /' &+*+0+ *#& '6#&'.

N# 5435/3# *'&' #8+$01# # +#& + 2'6$' C $' '6#&', #&'6

/3='# # /3#, ' 7/'$'+ + DFI %'# $' /3'01#, # *+# ' '6#&' + '

'37/#' # +&'# /3=''.

/.&.@ De-er,$*a'(% )e !ar%-e*$)es

P'&' '$43+ # 5'&#+$+, #&'6 /3='' '6#&' # &/# in

natura. A '$43+ #&'6 +' +6 &*35''. O 6## /3='# # +5&# *#&

H%8^ (>?).



P'&' # *&+*'&# ' #3/01#, #&'6 6/&'# '*&#6''6+$+ >!% '

'6#&', +6 /6 E&3+$6+^+& + ! 6L, 5#6 ! 6L + 435##3 #*&#*35#, >! 6L +

:+'$# + +6 +%/' ++ 6'+&'3 # '%'# *#& /6 6$/#. A* ' '%'01#, #

5#$+# # &'$+&# *'&' /6 /$3 + +*'&'01# + > 6L +$2#3# +6 *'*+3

'3/6$#, + # 2#3/6+ # 5#6*3+# 5#6 4%/' +3'' *'&' *#+&#& +5'$# + !

6$/#. E6 +%/' # +' 3'2'%+6 5#6 4%/' +3'' +, '* &K +5'$#

+ ! 6$/# 5'', # 5#$+# # 3&'# (+6 '3%#1# */32+&='# 5#6 /3'# +

# '$&# P.A.) *'&' /6 8'31# 2#3/6&5# (! 6L) +$2#3# +6 *'*+3 '3/6$#.

P'&' 5#6*3+'& # 2#3/6+, #&'6 '5#$'# 6L + '5+#$' + # &+'$+ +

:+'$#.

A 3+/&' # 9&'$5# (6L + '5+#$' + 6L + :+'$#) # +' +6

+*+5##6+&# U3&#*+5 >!! ' ! $6,

O 5435/3# + 5'&#+$+ #' # +# '&'2 ' &6/3';

C'&#+$+ #' (6%) m D.O ('8#&8$5') .

/.&.? De-er,$*a'(% )e a*-%!$a*$*as e #la0%*$)es

P'&' '$43+ ' '$#5'$$' + 3'2#$+, #&'6 /3='' '6#&' #

&/# in natura. A '$43+ #&'6 +' +6 &*35''. O 6## /3='# # +5&#

*#& F&'$5 (>?"), 5#6# 6#&'# $' +'*' ' +%/&;

P'&' ' *&+*'&'01# + +'$#3 ?, #&'6 5#3#5'# 6L + 4%/'

+3'' +6 /6 8'31# 2#3/6&5# + >!! 6L + +'$#3 *'&' 5#6*3+'& # 2#3/6+.

P'&' ' *&+*'&'01# + HC3 >,M, # 6/&'# +6 /6 8'31# 2#3/6&5#

/6 *#/5# + 4%/' +3'', >, 6L + HC3 >M + 6' 4%/' +3'' *'&'

5#6*3+'& # 2#3/6+.

P'&' ' *&+*'&'01# + 3+/&' ' #3/01# +6 +*+5&##6+&# U3&#*+5

>!!, # 6/&'# '*&#6''6+$+ >% ' '6#&' 5#6 ! 6L ' #3/01#



+&'#&' + +'$#3 ? + HC3 >,M ($' *&#*#&01# + ";>). A #3/01# #

/86+' ' '%'01# *#& # 6$/#. L#%# '*, ' #3/01# # &'$+&' *'&' /6

8'31# 2#3/6&5# + !6L + 5#& 68'&. P'&' ' +&'01#, # 6'+&'3 *+&6'$+5+/

+6 /6' %+3'+&' *#& /6' $#+. O 6'+&'3 # 3&'# *'&' /6 E&3+$6+^+& (>

6L) +6*&+ +$2#3# 5#6 *'*+3 '3/6$#.

I6+''6+$+, &+'3=#/-+ ' 3+/&' # 9&'$5# (+'$#3 ? + HC3 >,N) +

+*# ' #3/01# +6 +*+5&##6+&# U3&#*+5 >!! ' $6 *'&' '$#5'$$'

+ Q $6 *'&' 3'2#$+.

O 5435/3# + '$#5'$$' + 3'2#$+ #' # +# '&'2 ' &6/3'; A8#&8$5' '#& + 3/01#@?",.

5 RESULTADOS E DISCUSSÃO

O &+/3'# ' '$43+ ' 5#6*#01# 5+$+6'3 # &/# + $#$

*#+6 +& 2+&5'# $' T'8+3' + .

T'8+3' ; C#6*#01# 5+$+6'3 # &/# + $#$.

+ARMETRO RESULTADOU6'+ "?,C$=' > (>%@>!!%)

P&#+$' , %@>!!% (,)V'6$' C >"," 6%@>!!%L*+# >,Q %@>!!% (>)

A05'&+ #32+ #' (AST) (in nat.) ?,> A05'&+ #32+ #' (AST) (3#3=.) ",? A05'& &+/#& (AR) (in nat.) ,



A05'& &+/#& (AR) (3#3='#) ,>

T'8+3' ; T+#& + 2'6$' C, 5'&#+$+, '$#5'$$' + 3'2#$+ # &/# $#$.+ARMETRO RESULTADOC'&#+$+ !, 6%@>!!% (,Q W%@>!!%) A$#5'$$' !," 6%@>!!%F3'2#$+ >,Q 6%@>!!%

A *#3*' # &/# + $#$ '*&++$#/ '3' '' + /6'+, "?, (T'8+3'

) 5'&'5+&5' 5#6/6 + &/# &#*5', 5#6# ' '5+&#3' (Malig"ia *.)

(NOGUEIRA et al ., >??), ' 8'$'$' (Musa *.) + ' 3'&'$' (Citrus *.)

(VASCONCELLOS et al ., >???). O 2'3#& # +#& + /6'+ # &/# + $#$ +

"?,, 6#&'# $' T'8+3' , +4 *&6# 5#6 # #8# $' 3+&'/&' *'&' *#3*'

+ &/# '$43#%# (5'/ – "", '5+&#3' – ?>, *#3*' + %&'2#3' – "?, 3'&'$'

*K&' – ?!, 6'61# *'*'' – "?) + '5#&# 5#6 ' TACO (!!), +68#&' ++

&+/3'# +' 6/# /*+&#& '# &+/3'# +$5#$&'# *#& L'2'/ + L'2'/ (!!)

7/+ '&6'6 7/+ # &/# # $#$ *#/ '*&#6''6+$+ + /6'+.

E$&+'$#, ++ &+/3'# 1# 5#6*'2+, /6' 2+= 7/+ ' 5#6*#01# 7/65'# $#$ +&+ %&'$+6+$+ 5#6 ' *'&+ ' *3'$' (CUSHMAN + CHEUNG, >?Q>).

A+6', ' 5#6*#01# 7/65' # &/# # $#$ +*+$+ + 24&# '#&+,

$53/$# +*5+, #3#, 536', 6'/&'+ # &/#, *&#/01# + +#5'%+6 (_ANG +

SU, !!>).

D+ '5#&# 5#6 C+55: (!!), # 5#$+# + /6'+ + &/# 2'&' +

' ?. O $#$, *#&'$#, +$5#$&'-+ +$&# +' '' + /6'+. A

++&6$'01# + /6'+ /6' ' 6+' 6' 6*#&'$+ + /3='' $'

'$43+ + '36+$#.

C#6# 2# $' T'8+3' , ' 5$=' +$5#$&'' #&'6 + > (>%@>!!%), #

7/+ + '+6+3:' 7/'$'+ + 5$=' + #/&# &/#, +$5#$&'' $'

3+&'/&', ' 5#6# ' 8'$'$' *&'', # 6'&'5/4 + # *+7/ (!," %@>!!% 5''), # 5#5#

2+&+ (>%@>!!%), # 5/*/'0/ (>, %@>!!%), + '5#&# 5#6 ' TACO (!!), + # '8'5'

(GONDIM et al., !!).



C+55: (!!) '&6' 7/+ # 5#$+# + 5$=' #' +6 &/' &+5'

2'&' + !, ' ,>. E6 &+3'01# '$43+ ++ 5#6*#$+$+, # &/# $#$ +4

+ '5#&# 5#6 # &++&# $' 3+&'/&'.

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TACO (!!).

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'*&++$#/ /6' 5#$5+$&'01# + >", 6%@>!!%, 5#6# 6#&'# $' T'8+3' ,

6#&'$# 7/+ # $#$ *#+ +& 5#$+&'# 5#6# /6' #$+ +3+2'' + 2'6$' C,

*# +%/$# A$&'+ et al. (!!), ' #$+ + 45# '5&85# 1# 53'5''

+6 +&+$+ $2+; #$+ +3+2'' 5#$K6 + >!! ' !! 6%@>!!%, #$+ 6'

5#$K6 + ! ' >!! 6%@>!!% + #$+ 8'' 5#$K6 + ' ! 6%@>!!%.



C#6*'&'$# # +#& + 2'6$' C # $#$ 5#6 #/&' &/', *#+

#8+&2'& 7/+ ' '5+&#3', + '5#&# 5#6 ' TACO (!!), # &/# 7/+, '*&++$'

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2'6$' C # &/# 7/+ 6' + '+6+3:' '# &/# + $#$ +6 &+3'01# '# +#&

+' 2'6$'. A3%/6' &/' 5#$:+5' *#& +&+6 8#' #$+ + 2'6$' C,

*#/+6 7/'$'+ 8+6 6+$#&+ 7/+ # &/# + $#$. S1# +3'; 3'&'$' *K&' (

6%@>!!%), 3'&'$' 8':' (? 6%@>!!%), 6'61# *'*'' (" 6%@>!!%) + 6++&5' (>>

6%@>!!%).

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W%@>!!%) + # *+7/ (>! W%@>!!%) 1# # 7/+ *#/+6 7/'$'+ 6'

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W%@>!!%) + ' 6'$%' (>!! W%@>!!%) '*&++$'6 +#& 8+6 6' +3+2'# 7/+ # &/#

+6 +/#.

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3'2#$+ (T'8+3' ).

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5'4 (!,Q 6%@>!!%) + 6'&'5/4 (>,! 6%@>!!%). P#&'$#, # 7/+ 6' + '+6+3:'

'# $#$ +6 &+3'01# '$#5'$$' 1# ' 5'4 + # 6'&'5/4, 7/+ '*&++$'6 #

+#&+ 6' +3+2'#. 4 # &+/3'# +$5#$&'# $++ +/# *'&' 3'2#$+,

#&'6; 6'&'5/4 (>," 6%@>!!%), 3'&'$' (Q,> 6%@>!!%), 361# (,? 6%@>!!%),

'8'5' (,"> 6%@>!!%) + 6'$%' (," 6%@>!!%). X/'$# '# 3'2#$+, # &/#

7/+ 6' + '+6+3:' '# $#$ # 6'&'5/4, 7/+ $# +/# 5'# '*&++$#/ #

6'#& +#& # &++&# 5#6*#$+$+. F# #8+&2'#, 5#$/#, 7/+ # $#$

'*&++$#/ +#&+ + '$#5'$$' + 3'2#$+ +6+3:'$+ '# &/# + 6'#&

+#& $++ 5#6*## # +/# + S32' (!!Q).



D+ '5#&# 5#6 C+55: (!!), ' &/' *#/+6 +6 6' + ' >

+ 5'&8#&'#, *&$5*'36+$+ $' #&6' + '5'&#+. O &+/3'# #8#

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,> (3#3='#). E6 &+3'01# '# '05'&+ #32+ #', # +#& + %35#+ $'

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+'*' /8+7a+$+ # 6'+&'3 5#$%+3'# /86+# ' /6 245/# *'&5'3,#5'#$'$# ' +5'%+6 # *&#/# *'&' '*&#6''6+$+ 8'+ 6'. I# '=

5#6 7/+ # $/&+$+ ++'6 *&++$+ +6 6'#& 5#$5+$&'01#, +2# '# 6+$#&

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S6+ et al. (!!>) +6 *+$5/3# + 5'/ 6'/&# (?,!).



8 CONCLUSES

N# *&++$+ +/#, # 5#$53/# 7/+ # &/# + $#$ +'5#/-+ +6

&+3'01# ' #/&# &/# &#*5' 5#$/6# $# 9&'3 7/'$# '# +#& + 2'6$' C,

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A36 #, 5#6# '3%/$ 5'&#+$+ *#+6 + 5#$2+&+& +6 2'6$' A

+ # $#$ '*&++$#/ ++ 5#6*#$+$+ +6 7/'$'+ +6+3:'$+ ' #/&#

&/# 5#$+&'# 5#6# #$+ ++, # *#+ /5'& ' /' 6*#&$5'

$/&5#$'3 &+3'''.

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# 7/+ +$'=' ' /' 6*#&$5' $/&5#$'3 6#&'' $' 3+&'/&'.



E6 &+3'01# '# +#& + /6'+, 5$=', 5'&8#&'# #', '05'&+

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+/# *'&' '& 5#$$/'+ ' ++ &'8'3:#, ' 5#6#; $2+%'& '

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$+&+'$+ $2+%'& ' 7/'$'+ '+7/'' *'&' # 5#$/6# ++ &/#.

A+6', ' &+'3='01# + 6' +/# &+3'5#$'# #5'+, '$#

# &/# 7/'$# + #/&' *'&+ ' *3'$', + /6' 6*#&$5', *# '$' $1# :4

5#$53/+ +$2' #8&+ ++ '/$#.



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CUSHMAN, D. _., CHEUNG, H. S.. S*+5&#*:##6+&5 ''^ '$ *&#*+&+ #

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++5. +KH-%,e)$!$*e, 2. >, *. >Q – , !!Q.

ELDRIDGE, 9'&8'&'. T+&'*' N/&5#$'3 *'&' P&+2+$01#, T&''6+$# +

R+5/*+&'01# # C$5+&. I$; MAHAN, L. b':3++$, ESCOTT-STUMP, S^32'. ra9se

al$,e*-%s7 *9-r$'(% )$e-%-era$a. >>< +. S1# P'/3#; R#5', *. ? – ?Q?, !!.

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#%%) !%l%rs. N+d Y#&f; A5'+65 P&+, *.>">-!Q, >?".

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&+*+' (" ') *#& 2' #&'3 +3 +&'5# '5/## + Morinda citrifolia +6 &'#

S*&'%/+ D'd3+^. Re0. T%4$!%l., 2. >?, *. Q – Q", !!.

MATA, M'&# E/'&# R.M. C'2'35'$, DUARTE, M'&' E3' M'&$, ANSELMO,

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A$$' S^32' R + R.M., OLIVEIRA, C'63' C'&#3 A8/7/+&7/+. O8+$01# + %&'2#3'

+6 * *+3# *&#5+# + 3#3='01#. Re0$s-a Bras$le$ra )e +r%)9-%s

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MCCLATCHEY, _33. F&#6 P#3^$+'$ H+'3+& # H+'3: F## S#&+; C:'$%$%

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MELO, R.C. +. D++&6$'01# + '05'& &+/#& +6 *&++$0' + '5'&#+. Bras$l

A'9!are$r%7 R# + '$+&#, 2. ??, $. , *. – >, >?".

MILLER, G. L. U+ # $&#'35^35 '5 &+'%+$ #& ++&6$'#$ # &+/5$%

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MtLLER, /3'$+ C+$+$#. T#5'+ R+*&#/2' ' Morinda citrifolia L$$. !!Q.

>! *. D+&'01# (M+&'# +6 F'&6'5#3#%') – S+#& + CK$5' 9#3%5',

U$2+&'+ F++&'3 # P'&'$4, C/&8', !!Q.

NANDHASRI, P., PA_A, b. b., bAE_TU9TIM, ., EAMCHANYA, C. .,

SATTAPONPUN, C. N/&'5+/5'3 *&#*+&+ # T:' jY#&k, Morinda citrifolia '$

jN#$k /5+ +&'5. J%9r*al %# S!$e*!e a*) Te!K*%l%3H, 2. Q, /**3. , *. Q? –", !!.

NAYAb, 9. S:2'$'$', SANDIFORD, S+2+, MAB_ELL, A$+&#$. E2'3/'#$ #

:+ _#/$-:+'3$% A52^ # E:'$#35 E&'5 # Morinda citrifolia L. L+'. eCAM

A)0a*!e A!!ess, *. > – , #5#8+&, !!Q.

NELSON, S5# C. Morinda citrifolia ($#$). S*+5+ P&#3+ #& P'55 I3'$

A%&##&+& .̂ A*&3, 2+&. . *. > – >?, !!.



NELSON, S5# C., ELEVITCH, C&'% R. N%*$ TKe C%,le-e G9$)e #%r

C%*s9,ers a*) Gr%ers. P+&6'$+$ A%&5/3/&+ R+#/&5+, !!. >> *.

NOGUEIRA, C.M.D., MAIA, G.A., OLIVEIRA, G.S.F., FIGUEIREDO, R._., ORIÁ,

H.F. C'&'5+&5' 5', 5#-7/65' + 7/65' + '5+&#3' # 53#$+ UFC.

C$*!$a A3r%*P,$!a7 F#&'3+=', 2.Q, $.>@, *. Q – "!, >??.

OETTERER, M'&3'. A/3'; 6#$# + '5'&+# – *&#*&+'+ # '05'&+.

ESALX@USP, *#$2+3 +6

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C#$/+$ # :+ F&/ # Morinda citrifolia (N#$). J%9r*al %# Na-9ral +r%)9!-s7 2.

", $. >, *. >Q! – >Q, !!.

RIVAS, M%'3' R#&%/+=, CÁRDENAS, M'&' 9#33, MONTEAGUDO, G+^L#&+$=#, FREIRE, P+&# S4$5:+=, GUERRA, R+%3' L8+3 L*+=, MACHADO,

9+3f^ V+&+5', COSTA, L/ D'=. E2'3/'5$ P&+53$5' +3 E+5# A$$3'6'#&#

+3 /%# + Morinda citrifolia L. Re0$s-a C9a*a +la*-. Me)., 2. + , $. >!, !!.

RODRIGUEZ, F&'$55# . M#&$, PINEDO, D8#&': M#&$. M# ^ &+'3' +

Morinda citrifolia L. ($#$). Re0. C9a*a +la*-. Me), 2. ?, $. , !!.

SCIENTIFIC COMMITTEE ON FOOD – SCF. E/&#*+'$ C#66#$. O*$#$ # :+

S5+$5 C#66++ #$ F## #$ T':'$ N#$g /5+. 9&/+33+, D+5+68+&, !!.

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6'#@'%#, !!>.

SILVA, /3'$' G'*'& A3'$ +. A2'3'01# ' '2'+ '$#'$+ + +#&+ +

*#3+$, '$#5'$$' + 5'&#+$+ + &/' *&#/=' $# $#&++ 8&'3+&#.



!!Q. M#$#%&'' (G&'/'01# +6 X/65') – U$2+&'+ E'/'3 # C+'&4,

F#&'3+=', !!Q.

SILVA, S'$&' R+%$' ', MERCADANTE, A&'$' Z. C#6*#01# + 5'&#+$+

+ 6'&'5/4-'6'&+3# (Passiflora edulis 3'25'&*') in natura. C$*!$a e Te!*%l%3$a

)e Al$,e*-%s7 C'6*$', 2. , $. , *. – ", + – +=., !!.

SIM[ES, A&'$# # N'56+$#, MENEZES, #2'$ 9'&8#', ANDRADE, +'$

C'&3# +, FREITAS, D'$' F+&&+&', COSTA, F&'$53+/# 9+=+&&' ', SOUZA,

P':3+2 A/%/# +. C'&'5+&='01# 7/65' + *+$5/3# + 5'/ 55*-Q +6

+&+$+ +4# + ++$2#326+$#. Caa-$*3a, M##&-RN, 2. >, $. >@, *. Q-Q", +=. !!>.

SOLOMON, N+3. S/6# + N#$ (Morinda citrifolia) &/# $/3'&; # &/# &#*5'3 +

>!> '*35'0+ 6+5$', G+$+2', D$re!- S%9r!e +9l$sK$*3 5==7 >???.

SOUZA FILHO, M+$ + S4 M#&+&' +, LIMA, '$5+ R8+&#, NASSU, R+$'' T+f#,

9ORGES, M'&' + F46'. N#' P&2'; A2'3'01# F5#-7/65' + S+$#&'3 +N5'&+ + F&/' N'2' ' R+%1# N#&+ + N#&++ # 9&'3; E/#

E*3#&'&#. Bra<$l$a* J%9r*al %# F%%) Te!K*%l%3H, 2. , *. >?->, !!.

STROHECbER, R., HENNING, H.M. A*al$s$s )e 0$-a,$*as ,6-%)%s

!%,r%a)%s. M'&; P'= M#$'32#, >?Q. "*.

SU, 9'#-N$%, PA_LUS, A3#$ D., UNG, H^/$-A:, bELLER, _33'6 .,M5LAUGHLIN, +&&^ L., bINGHORN, A. D#/%3'. C:+65'3 C#$/+$ # :+ F&/

# Morinda citrifolia (N#$) '$ T:+& A$#'$ A52 .̂ J%9r*al %# Na-9ral

+r%)9!-s, 2. ", $. , *. ? – ?, !!.

T'8+3' 8&'3+&' + 5#6*#01# + '36+$# – TACO @ NEPA – UNICAMP. V+&1#

II. C'6*$'; NEPA – UNICAMP, !!. >! *.



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VASCONCELLOS, L.M.H., LAURIA, D.C., SILVA, L.H.C., TADDEI, .F. R+3'01# +$&+

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, *. "?? – "?, >???.

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VOLTARELLI, 3# C., F+8&+ + I$3'6'01#. S$,s$% Se,$%l%3$a e

F$s$%a-%l%3$a Cl"*$!as. M+5$', R8+&1# P&+#, 5'*. >, 2. Q, $. >@, *. Q – ",

'$@/$, >??.

_ANG, M'$-Y$%, _EST, 9.., ENSEN, C.., NO_ICbI, D., CHEN, SU, PALU,

A.b., ANDERSON, G. Morinda citrifolia (N#$); A 3+&'/&+ &+2+d '$ &+5+$

'2'$5+ $ N#$ &++'&5:. A!-a +Kar,a!%l%3$!a S$*$!a, 2. , $. >, *. >>Q –

>>>, D+5, !!.

_'$%, M. Y., SU, C. C'$5+& *&+2+$2+ ++5 # Morinda citrifolia ($#$). A**. Ne

Q%r A!a). S!$ 2. ?, *.>>->", !!>.

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:+*'##5. %rl) J%9r*al %# Gas-r%e*-er%l%3H, 2. >, $. , *. > – >?,

!!.

_ESTENDORF, #:'$$+, EFFEN9ERGER, b':'&$', IZNAGUEN, H''$,

9ASAR, S63'. T#5#3#%5'3 '$ A$'3^5'3 I$2+%'#$ # N#$ (Morinda citrifolia)

F&/ /5+. J%9r*al %# A3r$!9l-9ral a*) F%%) CKe,$s-rH, 2. , *. ? – Q, !!Q.



YANG, ., PAULINO, R., ANbE-STEDRONSbY, S., A9A_I, F. F&++-&'5'3-

5'2+$%$% '52^ '$ #'3 *:+$#3 # $#$ (Morinda citrifolia -.) /5+ '$ *#d+&

$ *&#5+$% '$ #&'%+. F%%) CKe,$s-rH, 2. >!. *. ! – !", !!Q.

YANG, S:/-C:/'$, CHEN, T/-I, LI, b+$-^/#$, TSAI, T/$-5:/$%. C:'$%+ $

P:+$#35 C#6*#/$ C#$+$, R+/52+ C'*'5^ '$ ACE I$:8#&^ A52^ $ N#$

/5+ /&$% T&'5#$'3 F+&6+$'#$. J%9r*al %# F%%) a*) Dr93 A*alHs$s, 2. >,

$. , *. ?! – ?", !!Q.

YEMN, E. _., _ILLIS, A.. T:+ +6'#$ # 5'&8#:^&'+ $ *3'$ +&'5 8^

'$:&#$+. TKe B$%!Ke,$!al J%9r*al7 L#$#$, 2. Q, *. !" – >, >?.ZIN, Z. M#:, HAMID, A. A8/3, OSMAN, A., SAARI, N. A$#'2+ '52+ #

5:&#6'#%&'*:5 &'5#$ #8'$+ &#6 &##, &/ '$ 3+' # M+$%f// (Morinda

citrifolia L.). F%%) CKe,$s-rH. !!, 2. ?, *. >? – >Q".

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