Aula 07 08 09 2009 2
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07 - 08 - 09AULA AULA AULA 07 - 08 - 09AULA AULA AULA
. Profa Cristina Gevehr Fernandes. Profa Cristina Gevehr Fernandes
2009/22009/2
[email protected]@hotmail.com
. - . .www josie gepac blogspot com. - . .www josie gepac blogspot com
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IntroduçãoIntrodução
Terminologia Básica Terminologia Básica
Revisão Biologia Celular Revisão Biologia Celular – Alterações cadavéricas– Alterações cadavéricas
– Mecanismos de agressão celular Técnica Necropsia – Mecanismos de agressão celular Técnica Necropsia
AdaptaçãoAdaptação
-Acúmulos intra e extra celulares
NecroseNecrose
Calcificações
Distúrbios Circulatórios
Inflamação
Distúrbios do Crescimento Celular
Neoplasias
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Introdução Alterações cadavéricas Mecanismo de agressão celular Adaptação Celular Lesões celulares Reversíveis
Degeneração Hidrópica Lesões Irreversíveis
Necrose Acúmulos intra e extracelulares de Substâncias Distúrbios Circulatórios Inflamação Distúrbios do Crescimento Celular Neoplasias
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Pato G
eral - CG
F - 2
009/2
Lesão ReversívelLesão Reversível
Aumento da Aumento da Demanda FuncionalDemanda Funcional
AdaptaçãoAdaptação
Lesão IrreversívelLesão Irreversível
Agressão
Acúmulos de Acúmulos de substânciassubstâncias
Célula Célula NormalNormal
13-15
/10/20
09
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Degeneração Hidrópica
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Conceito
Sinônimos
Tumefação celular (cell swelling)
Degeneração vacuolar
Degeneração balonosa
13-15
/10/20
09P
ato Geral - C
GF
- 2009/2
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Pato G
eral - CG
F - 2
009/213
-15/1
0/2009
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Falha na regulação do volume celular Falha na bomba de Na++/K
13-15
/10/20
09P
ato Geral - C
GF
- 2009/2
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Falha na regulação do volume celular Falha na bomba de Na++/K
Baixa disponibilidade de ATP
Hipóxia/anóxia
Hipoglicemia
13-15
/10/20
09P
ato Geral - C
GF
- 2009/2
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Falha na regulação do volume celular Lesão na membrana celular
Ataque do complemento
Toxinas bacterianas
Agressão viral
Radicais livres
13-15
/10/20
09P
ato Geral - C
GF
- 2009/2
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C5
C5a
Ba Properidin
D
C3 P C3a
B
The Alternative Pathway
C3b C3bB C3bBb C3bBbP C3bBb3b
C5b
C4
C4aC2 C2b C3 C3a
The Classical Pathway
Antibody + C1qrs
C4b C4b2a C4b2a3b
13-15
/10/20
09P
ato Geral - C
GF
- 2009/2
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C6 C7C8
C9
C9
C9 C9 C
9
C9 C
9 C9 C9
C9
C9
C5
C5b
C5a
70-100 Å
13-15
/10/20
09P
ato Geral - C
GF
- 2009/2
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MacroscopiaMicroscopia
13-15
/10/20
09P
ato Geral - C
GF
- 2009/2
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Pato G
eral - CG
F - 2
009/213
-15/1
0/2009
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Pato G
eral - CG
F - 2
009/213
-15/1
0/2009
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13-15
/10/20
09P
ato Geral - C
GF
- 2009/2
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Aspecto macroscópico
Pato G
eral - CG
F - 2
009/2
Aspecto microscópico
13-15
/10/20
09
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Características ultra-estruturaisP
ato Geral - C
GF
- 2009/2
Célula normal
Degeneração
13-15
/10/20
09
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Características ultra-estruturaisP
ato Geral - C
GF
- 2009/2
NormalNormal DegeneraçãoDegeneração
13-15
/10/20
09
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Características ultra-estruturaisP
ato Geral - C
GF
- 2009/2
13-15
/10/20
09
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13-15
/10/20
09P
ato G
era
l - CG
F - 2009/2
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Necrose Oncótica
Apoptose
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Conceito
Mecanismos Lise enzimática
Coagulação protéica
13-15
/10/20
09P
ato Geral - C
GF
- 2009/2
Proteína normalProteína normal Proteína Proteína desnaturadadesnaturada
Proteínas Proteínas coaguladascoaguladas
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Pato Geral - CGF - 2009/2
Macroscópico
13-15
/10/20
09
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Pato
Geral - C
GF
- 2009/2
13-15
/10/20
09
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Pato
Geral - C
GF
- 2009/2
13-15
/10/20
09
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Microscópico
Alterações no citoplasma
normalnormal eosinofiliaeosinofilia
13-15
/10/20
09P
ato Geral - C
GF
- 2009/2
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Pato G
eral - CG
F - 2
009/2
Microscópico
Alterações no núcleo
PicnosePicnose CariorréxisCariorréxis CarióliseCariólise
13-15
/10/20
09
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Pato
Geral - C
GF
- 2009/2
PicnosePicnose
CarióliseCarióliseNormalNormal
13-15
/10/20
09
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Pato Geral - CGF - 2009/2
Necrose de coagulação
Necrose de liquefação
Necrose caseosa
Necrose da gordura
13-15
/10/20
09
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Conceito
Aspecto
13-15
/10/20
09P
ato Geral - C
GF
- 2009/2
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Pato G
eral - CG
F - 2
009/2
Forma: depende do padrão vascular local
13-15
/10/20
09
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Pato
Geral - C
GF
- 2009/2
13-15
/10/20
09
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13-15
/10/20
09P
ato Geral - C
GF
- 2009/2
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13-15
/10/20
09P
ato Geral - C
GF
- 2009/2
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13-15
/10/20
09P
ato Geral - C
GF
- 2009/2
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13-15
/10/20
09P
ato Geral - C
GF
- 2009/2
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Pato
Geral - C
GF
- 2009/2
13-15
/10/20
09
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Pato G
eral - CG
F - 2
009/213
-15/1
0/2009
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Pato G
eral - CG
F - 2
009/213
-15/1
0/2009
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Pato
Geral - C
GF
- 2009/2
13-15
/10/20
09
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Pato
Geral - C
GF
- 2009/2
13-15
/10/20
09
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Pato
Geral - C
GF
- 2009/2
13-15/10/2009
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Conceito
Sinônimos/exemplos
Aspecto
Pato G
eral - CG
F - 2
009/213
-15/1
0/2009
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Pato G
eral - CG
F - 2
009/213
-15/1
0/2009
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Pato
Geral - C
GF
- 2009/2
13-15
/10/20
09
![Page 47: Aula 07 08 09 2009 2](https://reader034.fdocumentos.tips/reader034/viewer/2022042614/5596f4161a28ab624b8b4695/html5/thumbnails/47.jpg)
Pato
Geral - C
GF
- 2009/2
Polioencefalomalacia Polioencefalomalacia dos Ruminantesdos Ruminantes
13-15
/10/20
09
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Pato G
eral - CG
F - 2
009/213
-15/1
0/2009
![Page 49: Aula 07 08 09 2009 2](https://reader034.fdocumentos.tips/reader034/viewer/2022042614/5596f4161a28ab624b8b4695/html5/thumbnails/49.jpg)
Pato G
eral - CG
F - 2
009/213
-15/1
0/2009
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Pato G
eral - CG
F - 2
009/213
-15/1
0/2009
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Pato
Geral - C
GF
- 2009/2
13-15
/10/20
09
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Pato G
eral - CG
F - 2
009/2
Ex.:Infarto miocárdio Ex.:Infarto miocárdio humanohumano
necrose de necrose de coagulaçãocoagulação
necrose de necrose de liquefaçãoliquefação
13-15/10
/2009
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Pato
Geral - C
GF
- 2009/2
13-15
/10/20
09
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Conceito
Aspecto
13-15
/10/20
09P
ato Geral - C
GF
- 2009/2
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13-15
/10/20
09P
ato Geral - C
GF
- 2009/2
![Page 56: Aula 07 08 09 2009 2](https://reader034.fdocumentos.tips/reader034/viewer/2022042614/5596f4161a28ab624b8b4695/html5/thumbnails/56.jpg)
Pato G
eral - CG
F - 2
009/213
-15/1
0/2009
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Pato G
eral - CG
F - 2
009/213
-15/1
0/2009
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13-15
/10/20
09P
ato Geral - C
GF
- 2009/2
![Page 59: Aula 07 08 09 2009 2](https://reader034.fdocumentos.tips/reader034/viewer/2022042614/5596f4161a28ab624b8b4695/html5/thumbnails/59.jpg)
Pato G
eral - CG
F - 2
009/213
-15/1
0/2009
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Pato G
eral - CG
F - 2
009/213
-15/1
0/2009
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Pato
Geral - C
GF
- 2009/2
13-15
/10/20
09
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13-15
/10/20
09P
ato Geral - C
GF
- 2009/2
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13-15
/10/20
09P
ato Geral - C
GF
- 2009/2
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Pato
Geral - C
GF
- 2009/2
13-15
/10/20
09
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Pato
Geral - C
GF
- 2009/2
13-15/10
/2009
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Pato
Geral - C
GF
- 2009/2
13-15
/10/20
09
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13-15
/10/20
09
Quanto ao mecanismo, qual a diferença entre a necrose caseosa e de liquefação? P
ato Geral - C
GF
- 2009/2
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13-15
/10/20
09
Conceito
Aspecto
Pato G
eral - C
GF
- 2009/2
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Pato
Geral - C
GF
- 2009/2
13-15
/10/20
09
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Conceito
Tipos
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13-15
/10/20
09
Tipos Gangrena seca
Pato G
eral - CG
F - 2
009/2
Ergotismo: toxina do fungo Claviceps purpurea
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13-15
/10/20
09P
ato Geral - C
GF
- 2009/2
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13-15
/10/20
09P
ato Geral - C
GF
- 2009/2
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13-15
/10/20
09Tipos Gangrena úmida
Pato G
eral - CG
F - 2
009/2
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13-15
/10/20
09
Gangrena gasosa
Pato G
eral - CG
F - 2
009/2
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13-15
/10/20
09P
ato Geral - C
GF
- 2009/2
![Page 77: Aula 07 08 09 2009 2](https://reader034.fdocumentos.tips/reader034/viewer/2022042614/5596f4161a28ab624b8b4695/html5/thumbnails/77.jpg)
13-15
/10/20
09P
ato Geral - C
GF
- 2009/2
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Conceito
![Page 79: Aula 07 08 09 2009 2](https://reader034.fdocumentos.tips/reader034/viewer/2022042614/5596f4161a28ab624b8b4695/html5/thumbnails/79.jpg)
Eliminação de células durante o desenvolvimento
como mecanismo homeostático de manutenção da população celular
como mecanismo de defesa em respostas imunes
eliminação de células com lesões letais
na senilidade
13-15
/10/20
09P
ato Geral - C
GF
- 2009/2
![Page 80: Aula 07 08 09 2009 2](https://reader034.fdocumentos.tips/reader034/viewer/2022042614/5596f4161a28ab624b8b4695/html5/thumbnails/80.jpg)
Pato
Geral - C
GF
- 2009/2
NormalNormal
NecroseNecrosefagócitofagócito
corpo corpo apoptóticoapoptótico
ApoptoseApoptose
13-15
/10/20
09
![Page 81: Aula 07 08 09 2009 2](https://reader034.fdocumentos.tips/reader034/viewer/2022042614/5596f4161a28ab624b8b4695/html5/thumbnails/81.jpg)
13-15
/10/20
09P
ato Geral - C
GF
- 2009/2
![Page 82: Aula 07 08 09 2009 2](https://reader034.fdocumentos.tips/reader034/viewer/2022042614/5596f4161a28ab624b8b4695/html5/thumbnails/82.jpg)
13-15
/10/20
09P
ato Geral - C
GF
- 2009/2
![Page 83: Aula 07 08 09 2009 2](https://reader034.fdocumentos.tips/reader034/viewer/2022042614/5596f4161a28ab624b8b4695/html5/thumbnails/83.jpg)
Pato
Geral - C
GF
- 2009/2
http://www.icb.ufmg.br/~pat/Apoptose.htmhttp://www.icb.ufmg.br/~pat/Apoptose.htm
13-15/10/2009
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13-15
/10/20
09P
ato Geral - C
GF
- 2009/2
![Page 85: Aula 07 08 09 2009 2](https://reader034.fdocumentos.tips/reader034/viewer/2022042614/5596f4161a28ab624b8b4695/html5/thumbnails/85.jpg)
Pato
Geral - C
GF
- 2009/2
13-15
/10/20
09