Dr. Marcelo Balancin - fosp.saude.sp.gov.br:443 · Mesotelioma Mesotelioma Mesotelioma Mesotelioma...

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Mesotelioma Mesotelioma Mesotelioma Mesotelioma Mesotelioma Mesotelioma Mesotelioma Mesotelioma Mesotelioma Mesotelioma Mesotelioma Mesotelioma Mesotelioma Mesotelioma Mesotelioma Mesotelioma Mesotelioma Mesotelioma Mesotelioma Mesotelioma Mesotelioma Mesotelioma Mesotelioma Mesotelioma Mesotelioma Mesotelioma Mesotelioma Mesotelioma Mesotelioma Mesotelioma Mesotelioma Mesotelioma Mesotelioma Mesotelioma Mesotelioma Mesotelioma Mesotelioma Mesotelioma Mesotelioma Mesotelioma Mesotelioma Mesotelioma Mesotelioma Mesotelioma Mesotelioma Mesotelioma Mesotelioma Mesotelioma Mesotelioma Mesotelioma Mesotelioma Mesotelioma Mesotelioma Mesotelioma Mesotelioma Mesotelioma Mesotelioma Mesotelioma Mesotelioma Mesotelioma Mesotelioma Mesotelioma Mesotelioma Mesotelioma Mesotelioma Mesotelioma Mesotelioma Mesotelioma Mesotelioma Mesotelioma Mesotelioma Mesotelioma Mesotelioma Mesotelioma Mesotelioma Mesotelioma Mesotelioma Mesotelioma Mesotelioma Mesotelioma Mesotelioma Mesotelioma Mesotelioma Mesotelioma Mesotelioma Mesotelioma Mesotelioma Mesotelioma Mesotelioma Mesotelioma Mesotelioma Mesotelioma Mesotelioma Mesotelioma Mesotelioma Mesotelioma Mesotelioma Mesotelioma Mesotelioma Mesotelioma Mesotelioma Mesotelioma Mesotelioma Mesotelioma Mesotelioma Mesotelioma Mesotelioma Mesotelioma Mesotelioma Mesotelioma Mesotelioma Mesotelioma Mesotelioma Mesotelioma Mesotelioma Mesotelioma Mesotelioma Mesotelioma Mesotelioma Mesotelioma Mesotelioma Mesotelioma Mesotelioma Mesotelioma Mesotelioma Mesotelioma Mesotelioma Mesotelioma Mesotelioma Mesotelioma Mesotelioma Mesotelioma Mesotelioma Mesotelioma Mesotelioma Mesotelioma Mesotelioma Mesotelioma Mesotelioma Mesotelioma Mesotelioma Mesotelioma Mesotelioma Mesotelioma Mesotelioma Mesotelioma Mesotelioma Mesotelioma Mesotelioma Mesotelioma Mesotelioma Mesotelioma Mesotelioma Mesotelioma Mesotelioma Mesotelioma Mesotelioma Mesotelioma Mesotelioma Mesotelioma Mesotelioma Mesotelioma Mesotelioma Mesotelioma Mesotelioma Mesotelioma Mesotelioma Mesotelioma Mesotelioma Mesotelioma Mesotelioma Mesotelioma Mesotelioma Mesotelioma Mesotelioma Mesotelioma Mesotelioma Mesotelioma Mesotelioma Mesotelioma Mesotelioma Mesotelioma Mesotelioma Mesotelioma Mesotelioma Mesotelioma Mesotelioma Mesotelioma Mesotelioma Mesotelioma Mesotelioma Mesotelioma Mesotelioma Mesotelioma Mesotelioma Mesotelioma Mesotelioma Mesotelioma Mesotelioma Mesotelioma Mesotelioma Mesotelioma Mesotelioma Mesotelioma Mesotelioma Mesotelioma Mesotelioma Mesotelioma Mesotelioma Mesotelioma Mesotelioma Mesotelioma Mesotelioma Mesotelioma Mesotelioma Mesotelioma Mesotelioma Mesotelioma Mesotelioma Mesotelio Mesotel Mesot Mes M Mesotelioma Mesotelioma Mesotelioma Mesotelioma Mesotelioma Mesotelioma Mesotelioma Mesotelioma Mesotelioma Mesotelioma Mesotelioma Mesotelioma Mesotelioma Mesotelioma Mesotelioma Mesotelioma Mesotelioma Mesotelioma Mesotelioma Mesotelioma Mesotelioma Mesotelioma Mesotelioma Mesotelioma Mesotelioma Mesotelioma Mesotelioma Mesotelioma Mesotelioma Mesotelioma Mesotelioma Mesotelioma Mesotelioma Mesotelio Mesotel Mesot Mes M Mesotelioma Mesotelioma Mesotelioma Mesotelioma Mesotelioma Mesotelioma Mesotelioma Mesotelioma Mesotelioma Mesotelioma Mesotelioma Mesotelioma Mesotelioma Mesotelioma Mesotelioma Mesotelioma Mesotelioma Mesotelioma Mesotelioma Mesotelioma Mesotelioma Mesotelioma Mesotelioma Mesotelioma Mesotelioma Mesotelioma Mesotelioma Mesotelio Mesotel Mesot Mes M Mesotelioma Mesotelioma Mesotelioma Mesotelioma Mesotelioma Mesotelioma Mesotelioma Mesotelioma Mesotelioma Mesotelioma Mesotelioma Mesotelioma Mesotelioma Mesotelioma Mesotelioma Mesotelioma Mesotelioma Mesotelioma Mesotelioma Mesotelioma Mesotelioma Mesotelio Mesotel Mesot Mes M Mesotelioma Mesotelioma Mesotelioma Mesotelioma Mesotelioma Mesotelioma Mesotelioma Mesotelioma Mesotelioma Mesotelioma Mesotelioma Mesotelioma Mesotelioma Mesotelioma Mesotelioma Mesotelio Mesotel Mesot Mes M Mesotelioma Mesotelioma Mesotelioma Mesotelioma Mesotelioma Mesotelioma Mesotelioma Mesotelioma Mesotelioma Mesotelio Mesotel Mesot Mes M Mesotelioma Mesotelioma Mesotelioma Mesotelio Mesotel Mesot Mes M a oma lioma telioma sotelioma Mesotelioma Mesotelioma Mesotelioma Mesotelioma Mesotelioma Mesotelioma Mesotelioma Mesotelioma Mesotelioma Mesotelioma Mesotelioma Mesotelioma Mesotelioma Mesotelioma Mesotelioma Mesotelioma Mesotelioma Mesotelioma Mesotelioma Mesotelioma Mesotelioma Mesotelioma Mesotelioma Mesotelioma Mesotelioma Mesotelioma Mesotelioma Mesotelioma Mesotelioma Mesotelioma Mesotelioma Mesotelioma Mesotelioma Mesotelioma Mesotelioma Mesotelioma a oma lioma telioma sotelioma Mesotelioma Mesotelioma Mesotelioma Mesotelioma Mesotelioma Mesotelioma Mesotelioma Mesotelioma Mesotelioma Mesotelioma Mesotelioma Mesotelioma Mesotelioma Mesotelioma Mesotelioma Mesotelioma Mesotelioma Mesotelioma Mesotelioma Mesotelioma Mesotelioma Mesotelioma Mesotelioma Mesotelioma Mesotelioma Mesotelioma Mesotelioma Mesotelioma Mesotelioma Mesotelioma Mesotelioma Mesotelioma Mesotelioma Mesotelioma a oma lioma telioma sotelioma Mesotelioma Mesotelioma Mesotelioma Mesotelioma Mesotelioma Mesotelioma Mesotelioma Mesotelioma Mesotelioma Mesotelioma Mesotelioma Mesotelioma Mesotelioma Mesotelioma Mesotelioma Mesotelioma Mesotelioma Mesotelioma Mesotelioma Mesotelioma Mesotelioma Mesotelioma Mesotelioma Mesotelioma Mesotelioma Mesotelioma Mesotelioma Mesotelioma a oma lioma telioma sotelioma Mesotelioma Mesotelioma Mesotelioma Mesotelioma Mesotelioma Mesotelioma Mesotelioma Mesotelioma Mesotelioma Mesotelioma Mesotelioma Mesotelioma Mesotelioma Mesotelioma Mesotelioma Mesotelioma Mesotelioma Mesotelioma Mesotelioma Mesotelioma Mesotelioma Mesotelioma oma lioma telioma sotelioma Mesotelioma Mesotelioma Mesotelioma Mesotelioma Mesotelioma Mesotelioma Mesotelioma Mesotelioma Mesotelioma Mesotelioma Mesotelioma Mesotelioma Mesotelioma Mesotelioma Mesotelioma Mesotelioma oma lioma telioma sotelioma Mesotelioma Mesotelioma Mesotelioma Mesotelioma Mesotelioma Mesotelioma Mesotelioma Mesotelioma Mesotelioma Mesotelioma oma lioma telioma sotelioma Mesotelioma Mesotelioma Mesotelioma Mesotelioma ATUALIZAÇÃO PARA PATOLOGIA CIRÚRGICA 2018 Dr. Marcelo Balancin Médico Assistente DAP HC-FMUSP Pós Graduando (DD) Departamento de Patologia FMUSP

Transcript of Dr. Marcelo Balancin - fosp.saude.sp.gov.br:443 · Mesotelioma Mesotelioma Mesotelioma Mesotelioma...

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ATUALIZAÇÃO PARA PATOLOGIA CIRÚRGICA 2018

Dr. Marcelo BalancinMédico Assistente DAP HC-FMUSP

Pós Graduando (DD) Departamento de Patologia FMUSP

CONFLITO DE INTERESSE

Acessoria Científica Roche Diagnósticos LATAM

0

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1900 1920 1940 1960 1980 2000 2020 2040

PubMed.gov "Mesothelioma"

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2018 – 695

31.8%

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PubMed.gov "Mesthelioma"AND "Target"

2010 – 21

2018 – 55

262%

ClinicalTrials.gov – 358 Trials (09/11/2018)

Riaz et al. Eur Resp J 2012; 40:965

ROTEIRO PARA PATOLOGIA CIRÚRGICA

Rever Critérios OMS 2015-2018 (Julho, Lyon)Mesoteliomas Bifásicos

BAP1Mesotelioma in situ

Grau Nuclear

Mesotélio Mesotélio Mesotélio Mesotélio Mesotélio Mesotélio Mesotélio Mesotélio Mesotélio Mesotélio Mesotélio Mesotélio Mesotélio

Sage et al. High-Throughput 2018; 7,20

Mesotélio Mesotélio Mesotélio Mesotélio Mesotélio Mesotélio Mesotélio Mesotélio Mesotélio Mesotélio Mesotélio Mesotélio Mesotélio

“Amianto”

Mesotélio

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Churgh A. OMS 2015

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Mesotélio

Mesotélio

Mesotélio

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Mesotélio

Classificação OMS (2015)

MESOTELIOMA MALIGNO DIFUSOEpitelioideSarcomatoideDesmoplásico

Bifásico

MESOTELIOMA LOCALIZADOEpitelioideSarcomatoideBifásico

MESOTELIOMA PAPILÍFERO BEM DIFERENCIADOTUMOR ADENOMATOIDE

Epitelioide Sólido Epitelioide Diciduoide

Brcic Arch Pathol Med 2018; 142

Epitelioide Pleomórfico Epitelioide Micropapilífero

Brcic Arch Pathol Med 2018; 142

Epitelioide Acinar Epitelioide Trabecular

Brcic Arch Pathol Med 2018; 142

Epitelioide Tubulopapilífero Epitelioide Anel de Sinete

Brcic Arch Pathol Med 2018; 142

Mesoteliomas “Benignos”

MENSAGENS PARA LEVAR (“TAKE HOME MESSAGES”)

Monte seus paineis com base na morfologiaNão é necessário história de exposição ou identificação de corpos

ferruginosos

Painel para ME é diferente de MSPara ME: 2 + ME e 2 + Adenocarcinoma

MEAbdome / Pelve: Tumor adenomatoide e Carcinoma de

células renaisTórax: Adenocarcinoma

MSSarcoma Sinovial, Sarcoma Pleomórfico, Melanoma

Desmoplásico, Carcinoma Sarcomatoide

Hiperplasia Atípica?Recomendar BAP1 e p16 FISH

Diagnóstico de M Bifásico em questionamento (“Grupo Transicional”)

ROTEIRO PARA PATOLOGIA CIRÚRGICA

Rever Critérios OMS 2015-2018 (Julho, Lyon)Mesoteliomas Bifásicos

BAP1Mesotelioma in situ

Grau Nuclear

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