Post on 03-Dec-2018
Fábio Porto neurologista
GNCC / CEREDIC HC/FMUSP
06/04/2016
Cognição e dor
Programa de Educação Continuada em Fisiopatologia e Terapêutica da Dor
2016Equipe de Controle de Dor da Divisão de Anestesia do Hospital das Clínicas da FMUSP
"Dor é uma experiência sensorial e
emocional desagradável associada
com danos reais ou potenciais em
tecidos, ou assim percepcionada como
dano.
Fenômeno subjetivo
International Association for
the Study of Pain
•Fenomenologia clínica dos transtorno de humor implica em redes ligadas a regulação do humor, ansiedade, medo, processamento de recompensa, atenção, motivação, resposta ao estresse, interação social e funções neurovegetativas (sono, apetite, energia, peso, libido).•Normalmente congruente com o humor.
Methods:
•40 MCI (amnestic and non-amnestic) evaluated pre-
and pos-AT
•Subjects performed a twice-a-week, moderate
intensity, AT program for 24 weeks.
•Assessment with ADAS-cog, a neuropsychological
battery, and evaluation of rBGMwith positron emission
tomography with 18F-fluorodeoxyglucose (18FDG-PET)
•Aerobic capacity maximal oxygen consumption
VO2max (mL/Kg/min)
Results
P < 0.001 (uncorrected for multiple comparisons) minimum of 10 voxels within the
cluster ** ACC: familywise error method (FWE) (pFWE = 0.04).
correlation (ACC vs PCC) = −0.51, p < 0.01
Copy Rey Figure (rho =−0.38, p = 0.016)
Visual memory (r = 0.38, p = 0.01)
Results
In a post-hoc analysis, an additional comparison was
performed between participants (before and after the AT
program) and a CG of cognitively normal older adults
from our institution (Pre-AT versus CG and Post-AT
versus CG).
Pre-AT v.s Control group: Hypometabolism in PCC
and Precuneus p(FEW) < 0.05
A typical finding in early Alzheimer diseaseMinoshima , et al., Ann Neurol. 2007
It plays a role in the descending modulation of
pain and in defensive behaviour.
Substância cinzenta periaquedutal